Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PARNANT

Financiado

Cerrado

Pathogenetic pathways in age related neurodegenerations as novel therapeutic tar...

Pathogenetic pathways in age related neurodegenerations as novel therapeutic targets for Parkinson s disease Parkinson’s disease (PD) is the second most common neurodegenerative disorder (after Alzheimer's) associated with oxidative stress and aging, and affects an estimated 1% of people worldwide over 60 years of age. The pathogenetic t... ver más

01/09/2021

Eurac Research

183K€

Presupuesto del proyecto: 183K€

Líder del proyecto

ACCADEMIA EUROPEA DI BOLZANO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-09-01

MSCA-IF-2018: Individual Fellowships

I+D

Cerrada hace 6 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

Eurac Research

183.47K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

MEFOPA European Project on Mendelian Forms of Parkinson s Disease 8M€ Cerrado

PARTHECOM New pathway and small-molecule compounds for Parkinson’s dis... 216K€ Cerrado

PDGENNI Gene Environment Interactions in the Etiopathogenesis of Par... 100K€ Cerrado

PID2019-108792GB-I00 DISECCION DE MECANISMOS PATOGENICOS EN LA ENFERMEDAD DE PARK... 192K€ Cerrado

NEURODOPA DEGEN Elucidating mechanisms of dopaminergic neuronal degeneration... 75K€ Cerrado

BFU2016-80870-P CARACTERIZACION MOLECULAR, CELULAR Y FUNCIONAL DE NEURONAS D... 242K€ Cerrado

Duración del proyecto: 29 meses Fecha Inicio: 2019-03-28
Fecha Fin: 2021-09-01

Líder del proyecto

ACCADEMIA EUROPEA DI BOLZANO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 183K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Parkinson’s disease (PD) is the second most common neurodegenerative disorder (after Alzheimer's) associated with oxidative stress and aging, and affects an estimated 1% of people worldwide over 60 years of age. The pathogenetic triggers of neurodegenerations are largely unknown. Current therapeutic interventions only partially alleviate symptoms and do not restore normal neuronal function or prevent progressive neurodegenerations. Identifying novel molecular targets and searching for therapeutic agents that block neurodegeneration and promote neuronal restoration is a key challenge in the field. I and the Host have together identified 51 candidate genetic loci associated with age-related neurodegenerations in PD model and PD patients, respectively. These candidate genes are evolutionarily conserved in both vertebrate and invertebrate animals. I hypothesize that some of these genes, via an evolutionarily conserved signal transduction pathway, alleviate the oxidative stress in the dopaminergic neurons and protect them against degeneration. This project combines my (C. elegans genetics) and Host (cell-based PD models) expertise to identify new genetic pathways that mediate protection against neurodegenerations during oxidative stress and aging. I expect that achieved goals of the proposal will be important discovery that should lead to novel therapeutic targeting for Parkinson’s disease, and other neurodegenerative proteinopathies. My long-term goal is to become an independent scientist and establish lab to find novel therapeutic targets and strategies for the diseases associated with oxidative stress, including PD. Gained research experience together with improving my teaching, mentoring and management skills during this fellowship will help me to achieve my goals and transition myself into independence.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores