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OPTIMAR

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OPTical Imaging of Molecular and signalling Activity in Real time application t...

OPTical Imaging of Molecular and signalling Activity in Real time application to flatfish metamorphosis Aquaculture is a sustainable means of generating high-quality fish to satisfy the growing global fish consumption. Flatfish are attractive species for aquaculture due to their high market value and consumer demand. However, abnorm... ver más

31/12/2022

CCMAR

148K€

Presupuesto del proyecto: 148K€

Líder del proyecto

CENTRO DE CIENCIAS DO MAR DO ALGARVE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-12-31

WF-01-2018: Widening Fellowships

I+D

Cerrada hace 6 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

CCMAR

147.82K€ | Lider

WORLD ELASTOMERS TRADE

306.17K€ | Participante

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Duración del proyecto: 45 meses Fecha Inicio: 2019-03-28
Fecha Fin: 2022-12-31

Líder del proyecto

CENTRO DE CIENCIAS DO MAR DO ALGARVE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 148K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Aquaculture is a sustainable means of generating high-quality fish to satisfy the growing global fish consumption. Flatfish are attractive species for aquaculture due to their high market value and consumer demand. However, abnormal development during metamorphosis is often a problem and has hampered the development of successful flatfish aquaculture. Hence, it is critical to understand the specific molecular signalling pathways associated with abnormal metamorphosis. Larval metamorphosis has been studied using histological sections and gene expression profiling. However, the first requires sacrificing fish and the latter uses pool of larvae. Hence, there is an increasing demand for 3D imaging tools to directly visualise the mechanisms of metamorphosis in whole live flatfish. This offers a unique opportunity for optical imaging (OI) modalities, which are becoming popular for imaging targeted biological processes in model organisms (e.g. zebrafish). However, their full potential for biology and non-model organisms is being overlooked. The vision for this fellowship is to develop a non-invasive OI tool for real-time 3D in vivo imaging, for studying the molecular mechanisms regulating flatfish metamorphosis. The project combines recent advances in the mathematics of forward and inverse problems, marine molecular biology and modern OI technologies, including selective plane illumination microscopy and optical projection tomography. The developed OI tools will provide clear high-resolution pictures from the inside of live flatfish. Accurate light propagation models and image reconstruction methods will be developed to obtain high-quality images of biological significance. Moreover, novel acquisition schemes will be implemented to enable real-time 3D imaging. Finally, the OI tools will be used for in vivo flatfish imaging to obtain markers of normal and abnormal metamorphosis. This is essential to establish a sustainable and profitable flatfish aquaculture industry.

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