Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

DIABESITY

Financiado

Cerrado

Obesity Type 2 diabetes and the increased risk of cancer and cancer related Mo...

Obesity Type 2 diabetes and the increased risk of cancer and cancer related Mortality the study of Molecular Mechanisms and potential therapeutic modalities. "Epidemiological studies have clearly demonstrated that obesity and Type 2 diabetes are associated with an increased risk of developing common cancers including breast and colon cancer. They are also associated with increased canc... ver más

30/09/2014

TECHNION ISRAEL I...

250K€

Presupuesto del proyecto: 250K€

Líder del proyecto

TECHNION ISRAEL INSTITUTE OF TECHNOLOGY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-09-30 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

TECHNION ISRAEL INSTITUTE O...

0.00€ | Lider

Proyectos interesantes

PIIN_T2D

Medical Technol...

Data Science

2M€ Cerrado

PID2019-110998RB-I00

Medical Technol...

Data Science

194K€ Cerrado

SiCMetabol

Medical Technol...

Data Science

1M€ Cerrado

P16 AND METABOLISM

Medical Technol...

Data Science

164K€ Cerrado

BFU2008-04043

Medical Technol...

Endocrinology

182K€ Cerrado

PID2021-125104OB-I00

Medical Technol...

Data Science

157K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

TECHNION ISRAEL INSTITUTE OF TECHNOLOGY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 250K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "Epidemiological studies have clearly demonstrated that obesity and Type 2 diabetes are associated with an increased risk of developing common cancers including breast and colon cancer. They are also associated with increased cancer related mortality. While the mechanisms involved in this association are not yet defined, insulin resistance, hyperinsulinemia, hyperlipidemia, hyperglycemia and inflammatory cytokines are thought to be involved. Our studies, using separate mouse models of obesity or Type 2 diabetes, have replicated the increased association of these conditions and breast cancer. We have shown that endogenous hyperinsulinemia maybe an important contributing factor in the increased cancer risk. We propose to extend these studies in a number of directions. Firstly to confirm the findings using a mouse colon cancer cell lines. We will also study metastases, using a specific breast cancer cell line that spreads to the lungs and colon cancer that spreads to the liver. In these mouse experiments we will use specific blockers to the insulin and IGF-1 receptors to determine if the role of endogenous hyperinsulinemia is indeed a major factor in metastases and through which receptor it propagates a signaling cascade. Studies on the molecular mechanisms will be carried out on cells in culture and in the tissue samples from the tumors and metastases from lung and liver. We have also developed a model of hyperlipidemia and cancer and preliminary studies in our model suggest that, hyperlipidemia maybe another contributing factor in the connection between obesity/Type 2 diabetes and cancer and cancer metastases. This model, using breast and colon cancer, will be studied to identify the causative connection between this metabolic disorder and cancer. Overall the plan is to identify specific causality that will help design new therapeutic agents to deal with the growing problem of cancer in obese and diabetic patients."

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores