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NUCLAGY

Financiado

NUCLEAR DYNAMICS OF AUTOPHAGY IN PLANT IMMUNITY

Autophagy is a major degradation and renewal system that controls cellular homeostasis and stress adaptation in eukaryotes. Emerging evidence indicates that autophagy is an integral part of the plant’s defence against pathogens an... ver más

25/04/2023

SWEDISH UNIVERSITY...

204K€

Presupuesto del proyecto: 204K€

Líder del proyecto

SVERIGES LANTBRUKSUNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-04-25

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

MSCA-IF-2019: Individual Fellowships

I+D

Cerrada hace 5 años

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2 Participantes

SWEDISH UNIVERSITY OF AGRICU...

203.85K€ | Lider

ALUCOIL

945.20K€ | Participante

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Últimas noticias

01-12-2024: REDES En las últimas 48 horas el Organismo REDES ha otorgado 1337 concesiones

01-12-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

01-12-2024: AEI En las últimas 48 horas el Organismo AEI ha otorgado 23 concesiones

Duración del proyecto: 36 meses Fecha Inicio: 2020-04-14
Fecha Fin: 2023-04-25

Líder del proyecto

SVERIGES LANTBRUKSUNIVERSITET

TRL 4-5

Presupuesto del proyecto 204K€

Descripción del proyecto Autophagy is a major degradation and renewal system that controls cellular homeostasis and stress adaptation in eukaryotes. Emerging evidence indicates that autophagy is an integral part of the plant’s defence against pathogens and thus, a promising target to improve disease resistance in crops. Research on plant autophagy has primarily focused on cytoplasmic targets and mechanisms, yet the degradation of nuclear components (nucleophagy) and the epigenetic regulation of autophagy have recently received growing attention in yeast and mammalian systems. Whether nuclear events are of similar importance for plant autophagy is unknown and therefore, the major question to be addressed in this project. The proposed research builds on my key finding that several isoforms of the Arabidopsis core autophagy protein 8 (ATG8) localize to distinct nuclear compartments. I aim to identify the nuclear ATG8 interactomes at normal and virus-induced conditions by affinity-immunoprecipitation and mass spectrometry analysis. Candidate interactors will be functionally analysed for their potential role as transcriptional/epigenetic regulators, cargo receptors, and nucleophagic substrates in response to Cauliflower mosaic virus and Cabbage leaf curl virus. I will also investigate how these pathogens intersect with nuclear functions to manipulate cytoplasmic events of autophagy during infection. The proposed project will be carried out at the Swedish University of Agricultural Sciences under supervision of Prof. Daniel Hofius, a leading scientist and expert in plant autophagy and immunity. Hence, the project provides an excellent opportunity to expand my knowledge and experience to autophagy, while the host lab will benefit from my strong expertise in plant virology and epigenetics. Together, this synergistic effort will reveal fundamental insights into the nuclear dynamics of autophagy in plant immunity, and uncover novel autophagic mechanisms for crop improvement.

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