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RSM-MICROSPHERE-IPSC

Financiado

Cerrado

Novel Strategies for Microsphere Mediated Cellular Control A Technology to gen...

Novel Strategies for Microsphere Mediated Cellular Control A Technology to generate induced pluripotent stem cells for Regenerative Medicine A crucial goal of regenerative medicine is to generate desired cells, to build a specific tissue, from pluripotent stem cells directly derived from a patient's cells. These cells are known as induced pluripotent stem (iPS) cells a... ver más

31/08/2015

UGR

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

UNIVERSIDAD DE GRANADA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 5513

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-08-31 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UGR

0.00€ | Lider

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Líder del proyecto

UNIVERSIDAD DE GRANADA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 5513

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto A crucial goal of regenerative medicine is to generate desired cells, to build a specific tissue, from pluripotent stem cells directly derived from a patient's cells. These cells are known as induced pluripotent stem (iPS) cells and they have a potential therapeutic use as they offer an alternative to the controversial use of embryonic stem cells and, additionally, they avoid the issue of immune rejection. Nowadays the finding of an efficient and safe transfection method to introduce the appropriate genes (Oct3/4, Sox2, c-Myc and Klf4) into adult cells to obtain pluripotent stem cells is a bottleneck that could limit the use of iPS cells in humans. There is a need for a safe method for the production of pluripotent cells from adult human cells. Herein the development of a non-viral method for generating iPS cells is proposed. The broad aims of this research project are the design of novel strategies (based on solid phase chemistry) for the application, exploitation and development of a generic microsphere cellular delivery system for the release of a desired therapeutic cargo (such as DNA and protein) into adult human cells to induce the formation of iPS cells. This aims will be carried on by applying the skills in cellular delivery systems that the applicant acquired during her stay at the University of Edinburgh (UK) as a Research Fellow for the last five years. The project is a multidisciplinary approach with a synthetic chemical part to be developed at the University of Granada, where the applicant has recently been incorporated as Lecturer in Medicinal and Organic Chemistry, and a biological part to be developed at the Andalusian Bank of Stem Cells in collaboration with Dr. Garcia Perez, an specialist in the area of reprogrammation. The project deals with a topic of interest in European Research as it faces the treatment of many diseases by applying regenerative medicine based in the formation of iPS cells.

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