Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

NERS

Financiado

Cerrado

Novel Electro Responsive Protein Separation Method with Magnetic Nanoparticles

Pharmaceuticals for cancer therapies and other diseases are very since the production of therapeutic molecules such as antibodies is costly and every production process needs to be developed individually. Especially purification p... ver más

31/12/2022

TUM

176K€

Presupuesto del proyecto: 176K€

Líder del proyecto

TECHNISCHE UNIVERSITAET MUENCHEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-12-31

MSCA-IF-2019: Individual Fellowships

I+D

Cerrada hace 5 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

TUM

176.04K€ | Lider

MASSACHUSETTS INSTITUTE OF T...

MIT

88.63K€ | Participante

Proyectos interesantes

RED2018-102417-T

Medical Technol...

Nanotechnology

Materials Scien...

20K€ Cerrado

MAT2008-06126

Nanotechnology

Medical Technol...

28K€ Cerrado

SUPRABIOMAT

Nanotechnology

Medical Technol...

100K€ Cerrado

BES-2012-051782

Nanotechnology

Medical Technol...

43K€ Cerrado

PDC2021-121135-I00

Nanotechnology

Medical Technol...

146K€ Cerrado

BES-2009-014930

Nanotechnology

Medical Technol...

43K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 32 meses Fecha Inicio: 2020-04-15
Fecha Fin: 2022-12-31

Líder del proyecto

TECHNISCHE UNIVERSITAET MUENCHEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 176K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Pharmaceuticals for cancer therapies and other diseases are very since the production of therapeutic molecules such as antibodies is costly and every production process needs to be developed individually. Especially purification processes, which make up to 80-90% of the whole production, need to be improved or new ideas need to be developed. Short peptide sequences, so called tags, can be used to create new purification strategies based on the biomolecule recognition of these sequences. Magnetic iron oxide nanoparticles are an interesting counterpart for peptide tags as their properties facilitate an easy handling and manipulation. The key to the design of high-affinity peptide tags lies in an in-depth understanding of surface-peptide recognition patterns. I developed such a magnetite-binding peptide tag which allows the purification of tagged model proteins from fermentation broths by changing the surrounding media. However, such pH and buffer switches might also alter the properties of pharmaceutically relevant proteins such as antibodies. The challenge of this project is to establish a novel elution process based on an electrical potential switch instead of a pH switch. The process contains the magnetic separation of proteins containing the peptide tags and the elution of proteins based on the change of tag-particle interactions with electric fields. The use of this system will help to understand the binding of proteins to iron oxide nanoparticles and the formation of an electrochemical double layer in external fields. The electrical double layer formation is not only interesting in biotechnological processes but for the understanding of electrochemical catalysis and energy storage. This idea might pave the way to completely new approaches in biomolecule recognition, protein detection and purification.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores