Novel coatings to prevent biofilm formation on urinary catheters based on nanoan...
Novel coatings to prevent biofilm formation on urinary catheters based on nanoantibiotics and quorum quenching compounds
NanoQuench project is about the development of alternative methods to coat indewelling medical devices to control microbial biofilms with relevance to clinical drug resistance. Biofilms are bacterial communities embedded in a self...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
RTI2018-099019-A-I00
DESARROLLO DE TECNOLOGIAS DE FLUJO CONTINUO BASADAS EN SISTE...
128K€
Cerrado
BIO2014-61515-EXP
ANTIBIOTICOS VIVOS FRENTE A PATOGENOS INTRACELULARES
30K€
Cerrado
PHOTO-IASIS
Nanoengineered coatings for visible light photocatalytic dis...
192K€
Cerrado
FORMAMP
Innovative Nanoformulation of Antimicrobial Peptides to Trea...
10M€
Cerrado
PID2020-114347RB-C31
DISEÑO Y SINTESIS DE NANOPARTICULAS MOLECULARES Y BIOMOLECUL...
133K€
Cerrado
MAT2013-49213-EXP
NANO-ERIZOS AUTOENSAMBLADOS BASADOS EN CELULOSA COMO BACTERI...
22K€
Cerrado
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
NanoQuench project is about the development of alternative methods to coat indewelling medical devices to control microbial biofilms with relevance to clinical drug resistance. Biofilms are bacterial communities embedded in a self-produced polymeric matrix that commonly grow on indwelling medical devices, such as catheters. This mode of growing is believed to be regulated by a quorum-sensing (QS) system, a unique mechanism of communication that bacterial cells use through the secretion and uptake of small hormone-like molecules, called autoinducers. Due to their innate resistance to the immune system and low susceptibility to antibiotics, the microbial biofilms are difficult to treat and are a major factor in the morbidity and mortality of most infectious diseases. Methods by which the initial stages of bacterial attachment and biofilm formation can be restricted or prevented are therefore needed. Technologies that avoid catheter biofilm formation are based mainly on the application of conventional antimicrobial agents. However, the high resistance of bacteria within the biofilm makes any single therapeutic intervention unlikely to have sufficient effect.
This project focuses on the development of an integrated technological platform comprising quorum quenching enzymes and novel antibacterial agents (nanoantibiotics), able to counteract biofilm formation and at the same time avoid development of bacterial resistance to the therapy. These functional compounds will be coated onto catheters via layer-by-layer technique or a novel ultrasonic process.