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Nanoengineered coatings for visible light photocatalytic disinfection of medical...

Nanoengineered coatings for visible light photocatalytic disinfection of medical devices Catheter-associated infections are characterized by the formation of a bacterial biofilm on their surface and are a major clinical problem today with huge socioeconomic implications. As a result, apart from longer hospital admissi... ver más

30/04/2022

192K€

Presupuesto del proyecto: 192K€

Líder del proyecto

KAROLINSKA INSTITUTET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-04-30

MSCA-IF-2019: Individual Fellowships

I+D

Cerrada hace 5 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

191.85K€ | Lider

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Duración del proyecto: 24 meses Fecha Inicio: 2020-04-06
Fecha Fin: 2022-04-30

Líder del proyecto

KAROLINSKA INSTITUTET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 192K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Catheter-associated infections are characterized by the formation of a bacterial biofilm on their surface and are a major clinical problem today with huge socioeconomic implications. As a result, apart from longer hospital admissions that dramatically increase healthcare costs, in order to fight these infections increased antibiotic drug doses are used. This approach places selective pressure on pathogens and, especially in nosocomial settings, facilitates the emergence of antimicrobial resistant bacteria that are more difficult, if at all possible, to treat. In fact, catheter-associated infections by antimicrobial resistant bacteria are potentially lethal, especially in patients with compromised immune system (cancer, HIV patients). So, there is an urgent societal and clinical need to reduce such infections. The target of this project is to re-engineer catheters that exhibit anti-biofilm properties due to the presence of an antimicrobial nanocoating. This coating will consist of a photo-active material that destroys the biofilm upon visible light irradiation. The light will be delivered on the catheter surface by an optical fiber through the catheter opening. This will enable biofilm destruction with a simple push of a button. The developed catheter here will revolutionize this field by reducing such catheter-associated infections, minimizing the emergence of drug resistant bacteria and improving the public health worldwide. The supervisor’s unique expertise in nanomaterial synthesis using flame spray pyrolysis (FSP), and in applying the resulting nanoparticles to specific biomedical applications combined with that of the applicant’s in nanoparticles and photocatalysis reassures a mutual benefit between the applicant and the host institute and enhances the feasibility of this proposal.

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