Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

NEURINFDNA

Financiado

Cerrado

Neuronal DNA double strand breaks as novel epigenetic actors roles in cognition...

Neuronal DNA double strand breaks as novel epigenetic actors roles in cognition health and neuro inflammatory diseases Cognitive deficits are manifested several years prior detecting any neuronal loss in neurodegenerative diseases or during persistent infections of the central nervous system (CNS). Accumulating evidence show that epigenetic altera... ver más

03/01/2018

CNRS

142K€

Presupuesto del proyecto: 142K€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2018-01-03

MSCA-IF-2014-EF: Marie Skłodowska-Curie Individual F...

I+D

Cerrada hace 10 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

CNRS

56.03K€ | Lider

INSERM

85.82K€ | Participante

Proyectos interesantes

BrainBreaks

Medical Technol...

Applied Physics

2M€ Cerrado

GENECARE

Medical Technol...

Applied Physics

2M€ Cerrado

SIDSCA

Medical Technol...

Applied Physics

2M€ Cerrado

MITODSBR

Medical Technol...

Applied Physics

358K€ Cerrado

PID2019-110116GB-I00

Medical Technol...

Applied Physics

123K€ Cerrado

CHROMATINREPAIRCODE

Medical Technol...

Applied Physics

2M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 32 meses Fecha Inicio: 2015-04-28
Fecha Fin: 2018-01-03

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 142K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cognitive deficits are manifested several years prior detecting any neuronal loss in neurodegenerative diseases or during persistent infections of the central nervous system (CNS). Accumulating evidence show that epigenetic alterations contribute to neuronal dysfunction, as they cause durable changes of the chromatin structure that affect gene expression. In this context, DNA double-strand breaks (DSBs) are now emerging as central regulators of neuronal epigenetics. My recent findings opened innovative perspectives of research. I showed that DSBs are not always associated with neuronal apoptosis, but rather constitute novel epigenetic signals that contribute to cognitive processes. To date, the role of DSBs in pathogen persistence and the mechanisms whereby DSBs affect neuronal function in the course of an infection are totally unknown. Here, we postulate that perturbations in sensing, production and/or repair of DSBs may underlie the behavioral impairment that is observed in many CNS infectious diseases. Persistent neuronal viral infections, such as Bornavirus or Herpesviruses alter neuronal function, sometimes without overt immune response. The underlying mechanisms may result from episomal persistence of the viral genome in interaction with neuronal chromatin, thereby hijacking the chromatin remodeling system of the host cell, or from the secretion of proinflammatory cytokines. Parasites such as Toxoplasma also persist in the CNS and cause behavioral impairment. Their long-lasting impact on neuronal function may involve the modulation of the epigenome. Here, we propose to analyze the role of DSBs in cognitive alterations that accompany neurological infectious diseases. In particular, we will: 1) characterize the role of pathogens and the associated immune response to neuronal localization of DSBs during CNS infections; 2) analyze which mechanisms of neuronal DSBs generation, detection and repair contribute to cognitive impairments in CNS infections.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores