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MiRACLE

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Cerrado

Multiplexed microRNA detection platform for early diagnosis and patient manageme...

Multiplexed microRNA detection platform for early diagnosis and patient management Early detection of disease on a population scale (screening) relies on highly sensitive testing, able to detect early molecular changes, coupled with cost-effectiveness that enables economic access to such testing at scale.The MiR... ver más

30/11/2025

TAU

Presupuesto desconocido

Líder del proyecto

TEL AVIV UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-06-01

ERC-2023-POC: ERC PROOF OF CONCEPT GRANTS Objective:Objectives:The ERC Proof of Concept Grants aim at facilitating exploration of the commerci...

I+D

Cerrada hace 2 años

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Duración del proyecto: 17 meses Fecha Inicio: 2024-06-01
Fecha Fin: 2025-11-30

Líder del proyecto

TEL AVIV UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Early detection of disease on a population scale (screening) relies on highly sensitive testing, able to detect early molecular changes, coupled with cost-effectiveness that enables economic access to such testing at scale.The MiRACLE project addresses these challenges by combining a breakthrough optical sensing approach for single-molecule detection with creative biochemistry and computation. The ground-breaking goal of this research proposal is to develop a robust diagnostic platform capable of detecting disease-induced changes in micro-RNA expression by counting individual RNA molecules directly in bodily fluids without the need for amplification.This innovation will be realized by a novel, computationally assisted single-molecule detection scheme that, unlike common single-molecule detection methods, enables detecting a full panel of biomarkers simultaneously in a single snapshot, offering ultimate sensitivity at exceptionally low-cost. These attributes make this technology suitable for large-scale population screening and health management.Promising preliminary results show that MiRACLE can detect and count individual RNA targets in mixtures of synthetic miRs in physiological sub-femtomolar concentrations. These preliminary results highlight the potential of this approach for ultra-sensitive early detection of disease and a provisional patent has been submitted.Within the proposed project a proof of principle will be performed on a cohort of lymphoma patients and healthy controls that will be classified by the miracle approach. The technology will be benchmarked against existing state-of-the-art methods such as RNA sequencing and quantitative PCR.

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