Multifunctional Nanotechnology for selective detection and Treatment of cancer
The aim of the MultiFun consortium is to develop and validate a novel and minimally-invasive nanotechnology system to improve cancer diagnosis and treatment. MultiFun nanotechnology is based on multifunctionalised magnetic nanopar...
ver más
ATOS SPAIN SA
Estudio, desarrollo, aplicacion y comercializacion de la informatica en todos sus aspectos, gestion de centros de procesos de datos y venta,...
TRL
4-5
| 130K€
Fecha límite participación
Sin fecha límite de participación.
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
PID2019-106845RB-I00
DISEÑO DE NANO Y MICROPLATAFORMAS MAGNETICAS CON EFECTOS SIN...
97K€
Cerrado
NoCanTher
Nanomedicine upscaling for early clinical phases of multimod...
7M€
Cerrado
PID2020-112685RB-I00
NANOMEDICINAS BASADAS EN NANOPARTICULAS PARA INMUNOTERAPIA E...
249K€
Cerrado
CTQ2008-03739
NANOPARTICULAS MAGNETICAS MULTIFUNCIONALES PARA LA LIBERACIO...
91K€
Cerrado
MAGNIFYCO
MAGNETIC NANOCONTAINERS FOR COMBINED HYPERTHERMIA AND CONTRO...
5M€
Cerrado
PDC2022-133036-I00
NANOABRICACION ESCALADA DE NANOCAPSULAS MAGNETOPLASMONICAS P...
150K€
Cerrado
Información proyecto MULTIFUN
Líder del proyecto
ATOS SPAIN SA
Estudio, desarrollo, aplicacion y comercializacion de la informatica en todos sus aspectos, gestion de centros de procesos de datos y venta,...
TRL
4-5
| 130K€
Presupuesto del proyecto
13M€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
The aim of the MultiFun consortium is to develop and validate a novel and minimally-invasive nanotechnology system to improve cancer diagnosis and treatment. MultiFun nanotechnology is based on multifunctionalised magnetic nanoparticles to selectively target and eliminate breast and pancreatic cancer (stem) cells. The improved magnetic features of the MultiFun magnetic nanoparticles will lead to potential medical applications such as contrast agents and magnetic heating inductors. Moreover, magnetic nanoparticles can be functionalised with ligands to increase their affinity towards cancer cells in order to facilitate diagnosis of tumours by MRI. Targeting peptides and antibodies will be employed, including antibodies against cancer stem cells leading to early cancer detection by MRI means. The same nanoparticles will be used simultaneously as functional nanocarriers and heating inductors in order to provide a combined therapeutic modality. The synergistic effects of drugs, peptides, small RNAs and heat will be evaluated to determine the effectiveness of different therapeutic combinations. Interestingly, the use of ligands will favour the specific application of the therapeutic modalities to cancer (stem) cells, increasing the effectiveness and reducing side effects. Thus, MultiFun multimodal therapeutic approach is designed to efficiently remove cancer cells, including cancer stem cells, from the tumour site. The toxicity of functionalised magnetic nanoparticles will be assessed in vitro and in vivo to warrant a safe use and shed some light on the risks. The distribution and activity evaluation of functionalised nanoparticles will be performed in human breast and pancreatic cancer xenograft models. The use of novel magnetic nanoparticles for biomedical applications provides opportunities for new instrumentation: 1) detection and quantification of magnetic nanoparticles in blood, urine and tissues, and 2) magnetic heating induction for raising cell temperature.