Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

4Dplus_Metaflux

Financiado

Multidimensional in vivo metabolic flux analyses: Resolving immune cells based o...

Multidimensional in vivo metabolic flux analyses: Resolving immune cells based on in vivo metabolic phenotypes The development of better immunotherapies is being hammered by our lack of understanding about immune cell metabolism in vivo at the sites of disease. We know that immune cell metabolism is pivotal in controlling immune function.... ver más

30/11/2024

TRINITY COLLEGE DU...

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

THE PROVOST FELLOWS FOUNDATION SCHOLARS THE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-11-30

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2022-POC2: ERC PROOF OF CONCEPT GRANTS2

I+D

Cerrada hace 2 años

0% 100% 100%

1 Participantes

TRINITY COLLEGE DUBLIN

150.00K€ | Lider

Proyectos interesantes

MetaboTract Improving cellular cancer immunotherapy using chemotactic me... 190K€ Cerrado

CANCER-DC Dissecting Regulatory Networks That Mediate Dendritic Cell S... 2M€ Cerrado

ICoMICS Individual and Collective Migration of the Immune Cellular S... 2M€ Cerrado

MOTM Metabolic optimisation of intra-tumoral T cell motility 212K€ Cerrado

NANODIAGNOSTIC Super-resolution microscopy for immune checkpoint inhibitors... 150K€ Cerrado

IOO - Improving IO IOO: a novel assay to predict patient response to immune che... 4M€ Cerrado

Últimas noticias

02-12-2024: AGENCIA-VALENCIANA-D... En las últimas 48 horas el Organismo AGENCIA VALENCIANA D... ha otorgado 1 concesiones

02-12-2024: CDTI En las últimas 48 horas el Organismo CDTI ha otorgado 4 concesiones

01-12-2024: REDES En las últimas 48 horas el Organismo REDES ha otorgado 1337 concesiones

Duración del proyecto: 19 meses Fecha Inicio: 2023-04-24
Fecha Fin: 2024-11-30

Presupuesto del proyecto 150K€

Descripción del proyecto The development of better immunotherapies is being hammered by our lack of understanding about immune cell metabolism in vivo at the sites of disease. We know that immune cell metabolism is pivotal in controlling immune function. For instance, disrupting Natural Killer cell metabolism prevents them from killing cancer cells. Cellular immunotherapies for diseases like solid cancer are underperforming and one central reason for this is the metabolic pressure exerted on immune cells in solid tumours. The core problem is that we cannot currently measure the metabolism of immune cells at the site of disease. As a result, the biopharma industry is ill equipped to design immmunotherapies that are effective at these sites in the face of the metabolic stress. My ERC-CoG project (DC_Nutrient) has developed a new type of nutrient uptake assay with single cell resolution that can be used to probe metabolism in vivo. This is highly informative because the uptake of nutrients is the first limiting step for cellular metabolism. The core advance in our approach is to use bioorthogonal chemistry to attach a fluorophore to the nutrient after it has been transported into the cell. This bypasses all the pitfalls and failings of previous attempts to develop such assays using fluorophore tags. This PoC will advance this technology to simultaneously measure the uptake of 3 separate nutrients into immune cells at the site of disease, all with single cell resolution. Combined with an in vivo measurement of protein translation this will provide 4 dimensions of metabolic flux analysis for each cell analysed by multiparmetric flow cytometry. This innovative idea will provide a licensable assay technology that will be of high value to the biopharma industry as it will enable preclinical mouse studies to gain a detailed understanding of the metabolic changes occurring in immune cells at the site of disease. This technology will drive innovation towards metabolically enhanced immunotherapies.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores