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Multi phenotype Analysis of Rare Variants devELopment of an analysis method an...

Multi phenotype Analysis of Rare Variants devELopment of an analysis method and software with implementation to large scale data to unravel pleiotropic genetic effects behind cardiometabolic traits The obesity rates are rapidly increasing worldwide concomitantly with rising prevalence of chronic diseases, including cardiovascular disease and type 2 diabetes. Individual trait genome-wide association studies of common variants... ver más

31/07/2016

IMPERIAL COLLEGE O...

222K€

Presupuesto del proyecto: 222K€

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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-07-31 No tenemos la información de la convocatoria

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Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 222K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The obesity rates are rapidly increasing worldwide concomitantly with rising prevalence of chronic diseases, including cardiovascular disease and type 2 diabetes. Individual trait genome-wide association studies of common variants (minor allele frequency, MAF>5%) have highlighted complex genetic relationships between related cardiometabolic phenotypes with an intriguing pattern of associated overlapping DNA sequence variant effects, which does not always follow the epidemiological correlations. Joint analysis of multiple correlated traits: (i) increases power for variant discovery; and (ii) facilitates dissection of the genetic mechanisms underlying multi-phenotype association signals, including evaluation of the evidence for pleiotropy. Multi-phenotype analysis methods for common variants have been proposed, however, with the current focus being in low-frequency and rare variants (MAF<5%/1%), novel method development for identification of such effects is required. The project has three goals: 1) To develop a multi-phenotype analysis method for rare variants and to test it on at least 20000 individuals directly available to me. The availability of high-throughput omics data, including sequencing data and serum metabolites, adds further challenges to the methods development, e.g. due to genotype uncertainty and hundreds of correlated traits. I will extend the methodological development to the methods for meta-analysis of rare variants, given the need to combine genetic effects across many individual studies; 2) To create an efficient publicly available software tool for the developed methods; 3) To dissect the genetic architecture behind cardiometabolic phenotypes by conducting a large-scale multi-phenotype meta-analysis of rare variant effects on metabolic traits within international consortia. This timely and highly relevant project will allow me to embark on an independent academic career in the field of statistical genetics where my research interests lie.

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