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Motor Rehabilitation Plasticity Hacking by Engineered stimulation of the brain d...

Motor Rehabilitation Plasticity Hacking by Engineered stimulation of the brain dUring Sleep wake cycle Brain lesions such as stroke and traumatic brain injury are a major cause of adult-onset disability. Physical therapy, together with robotic aided rehabilitation, is the gold standard for promoting motor recovery. Yet, half of the... ver más

15/05/2024

IIT

183K€

Presupuesto del proyecto: 183K€

Líder del proyecto

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-05-15

MSCA-IF-2020: Individual Fellowships

I+D

Cerrada hace 4 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

IIT

183.47K€ | Lider

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Duración del proyecto: 36 meses Fecha Inicio: 2021-04-19
Fecha Fin: 2024-05-15

Líder del proyecto

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 183K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Brain lesions such as stroke and traumatic brain injury are a major cause of adult-onset disability. Physical therapy, together with robotic aided rehabilitation, is the gold standard for promoting motor recovery. Yet, half of the affected individuals do not fully recover their daily living skills. Hope is provided by advanced neuroprosthetic devices, acting directly at the brain level to promote plasticity, but to date, they still fall short of producing long-lasting brain rewiring. The often neglected but close relationship between sleep, neural plasticity, pathogenesis, and recovery can constitute a key factor to advance treatment. Within this framework, the primary goal of this project is to devise and test a novel neuroprosthetic approach that monitors brain activity and the sleep-wake cycle (SWC) in order to deliver responsive and engineered electrical stimulation (ES) coded in time. To do this, we aim to: 1) investigate SWC architecture in animal models of brain lesion to better understand pathological modifications and to find privileged windows of neural plasticity to deliver therapeutic ES; 2) design, build, and test a closed-loop system capable of recording, processing and detecting SWC stages and electrographic events of interest (e.g. spindles), and also of delivering coordinated ES, including activity-dependent and time-coded stimulation, and; 3) evaluate the designed approach regarding its efficacy in providing long-lasting, robust, and safe motor rehabilitation to injured animals, while also obtaining a proof-of-concept in humans. Highly complementary skills from fellow and host will cooperate to carry in vivo electrophysiology experiments and technological development, while translational pilot experiments will be performed in close collaboration with partners in the medical field. Finally, secondments will provide additional training on state-of-the-art engineering of closed-loop systems and entrepreneurship in neurotechnology.

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