Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ENRICH

Financiado

Cerrado

Molecular receptors enrich methylated and acetylated peptides for ultra-sensitiv...

Molecular receptors enrich methylated and acetylated peptides for ultra-sensitive proteomics to explore the hidden modified proteome in disease Scientific studies indicate that inefficient epigenetic control is associated with a wide variety of non-communicable diseases (NCDs) like cancer, schizophrenia, and diabetes. Indeed, histone post translational modifications (PTMs... ver más

31/12/2027

UNIVERSITA DEGLI S...

Presupuesto desconocido

Líder del proyecto

UNIVERSITA DEGLI STUDI DI PARMA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-01-01

HORIZON-MSCA-2022-SE-01-01: MSCA Staff Exchanges 2022 ExpectedOutcome:

I+D

Cerrada hace 1 año

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

Participantes

UNIVERSITA DEGLI STUDI DI PA...

Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PRE2020-092083 Genomic, proteomic, transcriptomic alterations in growth con... 99K€ Cerrado

nbPTMs A multifaceted platform for exploring nucleotide based post... 2M€ Cerrado

SAF2011-22803 EL DNA METILOMA DEL GENOMA TRANSCRITO NO-CODIFICANTE EN CANC... 569K€ Cerrado

ChemProt-HLMS Chemical proteomics for universal profiling of histone lysin... 222K€ Cerrado

BFU2008-04131 CARACTERIZACION DE RNAS NO CODIFICANTES INVOLCUCRADOS EN EL... 109K€ Cerrado

RTI2018-094049-B-I00 DISRUPCION EPIGENETICA Y GENETICA DE LAS MODIFICACIONES DEL... Cerrado

Duración del proyecto: 47 meses Fecha Inicio: 2024-01-01
Fecha Fin: 2027-12-31

Líder del proyecto

UNIVERSITA DEGLI STUDI DI PARMA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Scientific studies indicate that inefficient epigenetic control is associated with a wide variety of non-communicable diseases (NCDs) like cancer, schizophrenia, and diabetes. Indeed, histone post translational modifications (PTMs) are crucial for many cellular processes including transcription and DNA repair. Thus, the ability to readily and reliably detect PTMs is crucial to better understand epigenetic processes and the complex functions of histone PTMs in human diseases. Mass spectrometry (MS) is the technique of choice to identify such modifications across the proteome. MS requires an enrichment step generally performed using antibodies, but these have several limitations such as high costs, batch-to-batch variability and data reproducibility. In a multidisciplinary effort ENRICH aims at developing new cost-effective, fast and efficient tools for the enrichment of post translationally modified proteins overcoming the current limitation. ENRICH will functionalize nanoparticles (NPs) with molecular receptors able to enrich PTM-containing peptides, derived from proteolytic digestion, for subsequent MS analysis. Concurrently, the ability and selectivity of the synthesized receptors and functionalized NPs will be evaluated via spectroscopic analyses. The ENRICH network gathers the expertise required to tackle this challenge. The consortium is composed of 9 high-level academic research groups from 2 different continents (Europe and America) and 2 highly innovative companies. By the seconding of 87 ERs/ERSs across Europe and worldwide, the aim is to capitalize on the consortium expertise in complementary fields such as chemical synthesis, spectroscopy, and proteomics. The network promotes an effective integrate training of researchers, boosting their career development, and promotes collaborations between the partners. The direct involvement of industries guarantees the timely exploitation of the results from research laboratories to innovative products.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores