Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MODELLING_JOINT_DEV

Financiado

Cerrado

Modelling Joint Development Integrating Biological and Mechanical Influences

Embryonic joint development is a complex process with several distinct stages. The first step occurs in the cartilage anlage, where chondrocytes at the presumptive joint site stop proliferating and become compacted to form what is... ver más

31/08/2011

FUNDACIO PRIVADA C...

154K€

Presupuesto del proyecto: 154K€

Líder del proyecto

FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA Otras actividades deportivas asociacion

TRL 4-5 | 50K€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2011-08-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

FUNDACIO PRIVADA CENTRE DE R...

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

MechJointMorph The role of mechanical forces induced by prenatal movements... 1M€ Cerrado

COMPLIMB A computational tool to elucidate the mechanobiological regu... 246K€ Cerrado

EVALVE Biomechanics and signaling in models of congenital heart val... 2M€ Cerrado

DPI2009-11792 COOPERACION DE LA BIOMECANICA Y LA MECANOBIOLOGIA PARA EL MO... 113K€ Cerrado

BONE-JOINT-MORPH Mechanobiology of Proprioceptive Regulation of Bone and Join... 183K€ Cerrado

BFU2014-52586-REDT RED DE EXCELENCIA EN MECANOBIOLOGIA 28K€ Cerrado

Líder del proyecto

FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA Otras actividades deportivas asociacion

TRL 4-5 | 50K€

Presupuesto del proyecto 154K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Embryonic joint development is a complex process with several distinct stages. The first step occurs in the cartilage anlage, where chondrocytes at the presumptive joint site stop proliferating and become compacted to form what is called the interzone. From the interzone, the synovial cavity develops. Once the cavity has been initiated, the surfaces of the opposing cartilage rudiments undergo gradual shape morphogenesis so that the ends of the two bones form a functioning, friction-minimising contact surface, i.e., a synovial joint. It has been shown that mechanical forces are essential for normal cavitation of the joint, while it is not yet clear whether mechanical forces are an essential influence for moulding of the articular surfaces. If embryos are immobilised prior to cavitation, the process does not occur, while if immobilisation is induced after the cavity has formed, the cavity regresses and the elements can become fused. In this application, I propose a computational simulation of joint development, modelling cavitation of the joint and morphogenesis of the articular surfaces based on the interactions between mechanical and biological factors. The aims of the project are to 1) characterise the developing joint in 3-D in the embryonic chick; 2) calculate the forces and biophysical stimuli active in the joint over several stages; 3) create 2-D model of simple joint, 4) alter mechanical state to corroborate model predictions; 5) investigate mechanosensitive molecules and genes, and 6) upgrade model to 3-D. Such a simulation will lead to a better understanding of joint development which would have significant consequences for medical applications such as osteoarthritis and tissue engineering. This project will enable me to become an expert at the interface between developmental biology and bioengineering, and equip me to become a successful researcher and principal investigator as a specialist in the mechanobiology of the developing limb.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores