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Mix and Match: One-step activation for targeted drug delivery

Current clinically approved drug delivery systems, such as liposome, PEGylated liposome, and polymeric micelle, predominantly rely on passive accumulation within tumor tissues by diffusion through the defective tumor vessels durin... ver más

28/02/2026

STICHTING RADBOUD...

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

STICHTING RADBOUD UNIVERSITEIT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 1 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-02-14

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2023-POC: ERC PROOF OF CONCEPT GRANTS

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STICHTING RADBOUD UNIVERSITE...

150.00K€ | Lider

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Duración del proyecto: 24 meses Fecha Inicio: 2024-02-14
Fecha Fin: 2026-02-28

Líder del proyecto

STICHTING RADBOUD UNIVERSITEIT

TRL 4-5

Presupuesto del proyecto 150K€

Descripción del proyecto Current clinically approved drug delivery systems, such as liposome, PEGylated liposome, and polymeric micelle, predominantly rely on passive accumulation within tumor tissues by diffusion through the defective tumor vessels during circulation. The targeting efficacy toward cancer cells is very limited due to their inadequate interaction with cancer cells. The attachment of targeting ligands to nanocarriers has demonstrated its effectiveness in enhancing binding affinity and, consequently, facilitating cellular uptake via receptor-mediated endocytosis. However, the conventional methods employed for ligand attachment suffer from harsh conditions, low efficiency, and limited control over ligand orientation. These drawbacks compromise the targeting performance and are believed to result in the current absence of a targeted drug delivery system on the market. In this project, we propose a simple, efficient, and mild attachment method to spontaneously activate on demand nanocarriers. This innovative approach has the potential to have a multi- level effect, first to revolutionize various fields, including drug delivery, diagnostics, and nanotechnology, by providing advanced tools for targeted therapies and diagnostics. Secondly, by developing novel methodologies that can be applied to existing technologies to enhance uptake, localization, and efficacy while minimizing systemic toxicity thus potentially shifting the health- economic balance for some treatments which were previously inaccessible.

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