Innovating Works

WOKEGATE

Financiado
Minimally invasive endoscopes for neuronal activity monImaging-assisted single-c...
Minimally invasive endoscopes for neuronal activity monImaging-assisted single-cell specific activity monitoring and optogenetic stimulation of deep brain structures in motile and awaken ani Severe neuronal disorders such as dementia affect more than 1 billion people globally and account for economic burden far exceeding that of cancer. Our only chance of treating dementia is improving our understanding of how brains... Severe neuronal disorders such as dementia affect more than 1 billion people globally and account for economic burden far exceeding that of cancer. Our only chance of treating dementia is improving our understanding of how brains function at diverse levels of complexity. This will only be possible through better technologies, which already reflects in synchronised actions worldwide, such as the US Brain Initiative and EU Human Brain project. The origin ERC project LIFEGATE has developed minimally invasive (hair-thin) endoscopes for advanced applications in neuroscience, and brought about a solid route to their commercial outreach. The instruments rely on state-of-the-art digital holographic methods combined with high-performance computing. They offer uniquely detailed observations in unprecedented depths of living, yet anaesthetized, animal models, making them particularly suitable to studies of connectivity of neuronal cells inside their natural environment. This proposal, entitled WOKEGATE, represents a powerful extension of this concept, enabling imaging-informed, single-cell specific activity monitoring and control of deep neuronal circuits in fully awake and behaving animals. The prospect is centred around a novel M3CF fibre probes which emerged within the origin ERC project LIFEGATE, outside its proposed research agenda. The project aims for (i) necessary technological amendments to incorporate this opportunity into the holographic endoscope geometries, (ii) a direct verification of this prospect in in-vivo studies through the network of existing research partners and (iii) paving the way for commercial translation of such empowered scientific instrumentation. Successful acquisition and execution of the WOKEGATE will enable future perspectives of this promising technology through new opportunities such as the EIC Accelerator grant. ver más
30/04/2024
LEIBNIZINSTITUT FU...
150K€
Perfil tecnológico estimado
Duración del proyecto: 22 meses Fecha Inicio: 2022-06-10
Fecha Fin: 2024-04-30

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-30
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2022-POC1: ERC PROOF OF CONCEPT GRANTS1
Cerrada hace 3 años
Presupuesto El presupuesto total del proyecto asciende a 150K€
Líder del proyecto
LEIBNIZINSTITUT FUER PHOTONISCHE TECHNOLOGIEN... No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5