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miRanDa

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microRNA assay system based on self assembled nanoscale DNA origami arrays

MicroRNAs (miRNAs) are potential biomarkers for cancer diagnosis, prognosis and treatment monitoring. Specific detection and absolute quantification of miRNAs is of clinical relevance for early cancer detection and monitoring prog... see more

31/05/2023

UNIFR

203K€

Project Budget: 203K€

Project leader

UNIVERSITE DE FRIBOURG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo H2020 notifico la concesión del proyecto The day 2023-05-31

MSCA-IF-2019: Individual Fellowships Objective:The goal of the Individual Fellowships is to enhance the creative and innovative potential...

I+D

Cerrada does 5 years

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIFR

203.15K€ | Leader

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Project duration: 38 months Date Start: 2020-03-11
End date: 2023-05-31

Project leader

UNIVERSITE DE FRIBOURG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 203K€

participation deadline Sin fecha límite de participación.

Project description MicroRNAs (miRNAs) are potential biomarkers for cancer diagnosis, prognosis and treatment monitoring. Specific detection and absolute quantification of miRNAs is of clinical relevance for early cancer detection and monitoring progression. The currently available techniques for miRNA detection based on DNA amplification are limited by lack of absolute quantification, low multiplexing capacity and time consumption. Here, I propose to develop a miRNA assay system based on self-assembled nanoscale DNA origami arrays (miRanDa) for the simultaneous detection of multiple miRNA targets from breast cancer cells and plasma by using DNA-PAINT, state-of-art super resolution technique. The formation of specifically configured finite 2D lattices of self-assembled DNA origami structures based on sticky-end hybridization will further improve the capacity of the detection system beyond the currently available techniques. This assay can be further developed and adapted to the rapid, specific, sensitive and multiple detection of additional nucleic acid species, such as ctDNA, mRNA or lncRNA.

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