Microfluidic Platform for Analyzing Sperm Flagellar Beating in a Chemical Gradie...
Microfluidic Platform for Analyzing Sperm Flagellar Beating in a Chemical Gradient
MicroBeaCh aims to exploit the biomimetic approach to unravel harmonized spermatozoa beating that favors natural fertilization. Biochemical stimuli in follicular fluid (FF) play a pivotal role in guiding sperm cells for their trav...
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Información proyecto MicroBeaCh
Duración del proyecto: 27 meses
Fecha Inicio: 2024-05-21
Fecha Fin: 2026-08-31
Líder del proyecto
BEEZ BIOTECH
No se ha especificado una descripción o un objeto social para esta compañía.
Presupuesto del proyecto
196K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
MicroBeaCh aims to exploit the biomimetic approach to unravel harmonized spermatozoa beating that favors natural fertilization. Biochemical stimuli in follicular fluid (FF) play a pivotal role in guiding sperm cells for their traversal through the cumulus-oocyte complex. FF contains peptides, proteins, steroid hormones, polysaccharides, metabolites, antioxidants, and reactive oxygen species. Despite some preliminary investigations and the potential advantages afforded by microfluidics approaches, a noticeable dearth exists in the unravelling mechanism of spermatozoa beating. MicroBeaCh intends to explore the fundamental beating contributions of the sperm cell before penetrating the cumulus-oocyte complex. This will be the first study exploiting computer vision and artificial intelligence with a biomimetic chemical landscape to obtain the signature wavelets arising with the cumulus cells and with individual biochemicals (including some growth factors and hormones) inspired from the composition of FF. We believe that the successful accomplishment of MicroBeaCh will establish the foundation of novel parameters for quality sperm selection in application to assisted reproduction where the identification of specific wavelets will advance the outcomes of the practices. Success of MicroBeaCh will encourage the ER to acquire translational research and entrepreneurship skills. Joint efforts of ER and the host will assure the exploitation of results obtained from MicroBeaCh.