Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CHANNELMAT

Financiado

Cerrado

Microchannels for controlling cellular mechanotransduction

Cells respond to external mechanical stimuli through an activation of a cellular mechanism called mechanotransduction. The cellular responses in this mechanism are expressed by a modification in cellular proliferation, migration a... ver más

31/03/2019

CAU

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

CHRISTIANALBRECHTSUNIVERSITAET ZU KIEL No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-03-31

ERC-2017-PoC: ERC-Proof of Concept

I+D

Cerrada hace 8 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CAU

150.00K€ | Lider

Proyectos interesantes

DPI2017-84780-C2-1-R

Medical Technol...

Materials Scien...

121K€ Cerrado

RTI2018-096794-B-I00

Medical Technol...

Materials Scien...

73K€ Cerrado

PID2021-123013OB-I00

Medical Technol...

Materials Scien...

157K€ Cerrado

MACxercise

Medical Technol...

Materials Scien...

1M€ Cerrado

MAT2011-23819

Medical Technol...

Materials Scien...

170K€ Cerrado

ANGIOSCAFF

Medical Technol...

Materials Scien...

15M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 18 meses Fecha Inicio: 2017-09-20
Fecha Fin: 2019-03-31

Líder del proyecto

CHRISTIANALBRECHTSUNIVERSITAET ZU KIEL No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cells respond to external mechanical stimuli through an activation of a cellular mechanism called mechanotransduction. The cellular responses in this mechanism are expressed by a modification in cellular proliferation, migration and differentiation, as well as in a strengthening of their adhesion. Likewise, diseases such as cancer and cardiac dysfunctions are also related to cellular mechanotransduction. Here we propose to take a novel 3D material porous material towards commercial applications. The material serves as a platform for controlling mechanotransduction (e.g. in implant materials) and enables a control of mechanotransduction by mimicking natural 3D cellular environments. Our material contains a novel form of microporous structures represented by micron-sized channels embedded in a polymer matrix of a well-defined stiffness that has been developed within the ERC project CELLINSPIRED. The material guarantees pore interconnectivity independently of pore density and size, a unique feature offered by our fabrication procedure, for which we have applied for a patent (EP 15166793.8, PCT/EP2016/060160). Furthermore, it also provides a large, three-dimensionally controlled cell-surface contact area, such that the mechanical properties of the environment will have large impact on the cells. Our goal in this project is to validate our novel material for cellular applications where mechanotransduction is targeted. The expected outcome of our project is to receive a demonstrator material that (1) has well-defined mechanical properties, porosities and pore dimensions, (2) is biocompatible and can be sterilized, (3) can be fabricated in different levels of complexity, (4) can activate mechanotransduction in cells, and (5) can be fabricated using high-throughput processes. As for commercialization, we aim to license the patent to biomaterials companies involved in applications that range from 3D cell cultures to implant materials.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores