Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MeLiLoN

Financiado

Metabolic Networks that Link Longevity to Reproduction in Response to Nutrition

In most western countries, life expectancy is increasing by 3 months a year. As the average age of the population increases, so too does the prevalence of age-related diseases such as cancer, cardiovascular and metabolic diseases,... ver más

30/09/2020

CNRS

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-09-30

ERC-CoG-2014: ERC Consolidator Grant

I+D

Cerrada hace 10 años

0% 100% 100%

2 Participantes

CNRS

1.94M€ | Lider

ONITY

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PID2021-127792NB-I00 INTEGRATIVE GENIC ANALYSIS OF LONGEVITY IN HUMANS, PRIMATES,... 242K€ Cerrado

PID2019-108858RB-I00 ESTILO DE VIDA, OMICAS Y AUTOFAGIA PARA UN CEREBRO SANO EN U... 145K€ Cerrado

SAF2016-80532-R ANALISIS OMICO INTEGRADO DE LOS EFECTOS DE LA DIETA MEDITERR... 97K€ Cerrado

SAF2013-44663-R IDENTIFICACION DE BIOMARCADORES DE FRAGILIDAD Y DE ESTRATEGI... 218K€ Cerrado

BFU2017-88615-P ENTENDIENDO INTERVENCIONES QUE PROLONGAN LA ESPERANZA DE VID... 170K€ Cerrado

ElucidAge Elucidating and targeting the mechanisms encoded in the geno... 2M€ Cerrado

Duración del proyecto: 62 meses Fecha Inicio: 2015-07-30
Fecha Fin: 2020-09-30

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto In most western countries, life expectancy is increasing by 3 months a year. As the average age of the population increases, so too does the prevalence of age-related diseases such as cancer, cardiovascular and metabolic diseases, and neurodegenerative disorders. An essential component of ageing research is to understand the biological mechanisms that contribute to the ageing process at the cellular and molecular levels. This has major implications not only for the treatment of age-associated diseases but also for the promotion of healthy ageing. Studies of experimental animals and observations in humans have identified an array of genes and nutritional conditions that increase lifespan. However, these manipulations (genetic or nutritional) often have detrimental effects on other biological processes; for example, reproduction, metabolism, immunity or growth. This is an area of ageing research that has largely been ignored but that is critical to the success of strategies intended to slow ageing and thus the onset of disease. The primary goal of this research proposal is to understand how lifespan extension is linked to reproduction. We will use the nematode Caenorhabditis elegans as a model organism to identify novel conserved genes, molecules, and metabolic networks that link reproduction and longevity through nutrition. The proposed study is based on a unique set of preliminary data that identifies the first clear molecular links between these traits: a steroid hormone receptor and a reproduction-responsive lipase, both of which modulate lifespan extension achieved through changes in nutrition. Understanding the regulation and function of these genes and pathways will clarify at the molecular level how reproduction is linked to longevity. This may ultimately lead to interventions that optimise metabolic activity to promote healthy ageing.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores