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M-P Communication

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Maternal paternal communication in cattle understanding how male induced enviro...

Maternal paternal communication in cattle understanding how male induced environmental changes in the female reproductive tract influence reproductive success Infertility is a worldwide problem affecting the cattle industry. After successful insemination, embryonic and foetal mortality take place in about 50% of the cases, with most of these losses occurring before implantation. Due to... ver más

31/08/2020

UDG

170K€

Presupuesto del proyecto: 170K€

Líder del proyecto

UNIVERSITAT DE GIRONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 227

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-08-31

MSCA-IF-2017: Individual Fellowships

I+D

Cerrada hace 7 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UDG

170.12K€ | Lider

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Duración del proyecto: 29 meses Fecha Inicio: 2018-03-02
Fecha Fin: 2020-08-31

Líder del proyecto

UNIVERSITAT DE GIRONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 227

Presupuesto del proyecto 170K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Infertility is a worldwide problem affecting the cattle industry. After successful insemination, embryonic and foetal mortality take place in about 50% of the cases, with most of these losses occurring before implantation. Due to beef and dairy constituting 20.8% of the EU agricultural output, reproductive inefficiency translates into a tremendous social and bioeconomic impact. Although many factors can be involved in preimplantation loss, there is increasing evidence for the role of the maternal immune system and its regulation by seminal plasma (SP). Studies in rodents, humans and pigs have described beneficial effects of SP in improving embryo development and implantation. However, evidence for a role of SP in fertility in cattle, where removal of SP before artificial insemination is routine, is relatively weak. Thus, this project will use a model of heifers mated to vasectomised or intact bulls, to study the role of SP in paternal-maternal communication as it pertains to embryo development and immune modulation. To accomplish this task, a talented Fellow will join a leading laboratory in male reproductive physiology where she will build on her existing skills and acquire new multidisciplinary competencies. An ambitious, yet realistic, work plan has been designed based on the excellent background of the Fellow and the training she will receive, the expertise of the supervisor in male reproductive physiology, and the infrastructure within the host lab for conducting all the experiments with the most appropriate tools. This will ensure that the Fellow completes the scientific objectives of the proposal, communicate and disseminate the results to the scientific and general public, while acquiring a new set of skills that will have a dramatic impact in her career development. If the beneficial effects of SP on fertility is recapitulated in cattle, the associated increased production and efficiency could have a tremendous impact in the beef and dairy industries.

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