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LIGNIN-IB-PEROXIDASE

Financiado

Ligninolytic Enzymes: Keys to unlock the hidden potential of lignin

Context: Globally, 50-70 million tons of lignin, a highly branched heteroaromatic polymer, are discharged per year as a waste material from the paper and pulp industry despite being touted as the most abundant renewable source of... ver más

01/09/2026

TU WIEN

184K€

Presupuesto del proyecto: 184K€

Líder del proyecto

TECHNISCHE UNIVERSITAET WIEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-04

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023

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TU WIEN

183.60K€ | Lider

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Últimas noticias

01-12-2024: REDES En las últimas 48 horas el Organismo REDES ha otorgado 1337 concesiones

01-12-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

01-12-2024: AEI En las últimas 48 horas el Organismo AEI ha otorgado 23 concesiones

Duración del proyecto: 29 meses Fecha Inicio: 2024-03-04
Fecha Fin: 2026-09-01

Líder del proyecto

TECHNISCHE UNIVERSITAET WIEN

TRL 4-5

Presupuesto del proyecto 184K€

Descripción del proyecto Context: Globally, 50-70 million tons of lignin, a highly branched heteroaromatic polymer, are discharged per year as a waste material from the paper and pulp industry despite being touted as the most abundant renewable source of different value-added products on earth. Leaving 98% of lignin underutilized, industries degrade only 2% of lignin and that also comes with environmentally hazardous thermochemical processes. Background: Recently, the discovery of heme-containing class II fungal peroxidases viz. lignin peroxidase (LiP), manganese peroxidase (MnP), versatile peroxidase (VP), dye-decolorizing peroxidase (DyP) garnered a lot of attention due to their biodegradable ligninolysis. However, the industrial application of peroxidase-based lignin degradation still seems to be a far-flung dream owing to low availability of peroxidases in sufficient amount, enzyme instability in industrial effluent, high enzyme cost and long process times. Aims and objective: I hypothesize that a cocktail of engineered stress tolerant, active and stable peroxidases could lead to synergistic biodegradation of lignin. To achieve this, artificial intelligence (AI) tailored LiP, MnP, VP and DyP will be cloned and expressed as inclusion bodies (IBs) in E. coli using Prof. Spadiut’s expertise whereas mine will employ solubilization and refolding strategies to increase the overall yield of bioactive protein. An ideal stoichiometric combination of engineered peroxidases will be standardized to withstand the harsh conditions of industrial effluent, resulting in a sustainable and economic ligninolytic technology. Concluding remarks: The project is inspired from nature, backed with AI and stemmed with the expertise of mine and Prof. Spadiut’s in producing recombinant bioactive protein from bacterial IBs while TU Wien’s decades of experience in commercializing the technology will be a fertile playground to bow the seeds of a sustainable ligninolytic technology.

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