Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

IntraMAP

Financiado

Cerrado

Intramer-mediated multi-parallel mapping of signalling pathways

Cellular behaviour is methodically studied using systems biology approaches that analyse the presence, absence, or oscillation of biomolecules. To this end, exogenous perturbations, among others, are used to alter protein expressi... ver más

30/09/2029

RHEINISCHE FRIEDRI...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

RHEINISCHE FRIEDRICHWILHELMSUNIVERSITAT BONN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-10-01

ERC-2023-ADG: ERC ADVANCED GRANTS Scope:Objectives

I+D

Cerrada hace 1 año

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

Participantes

RHEINISCHE FRIEDRICHWILHELMS...

Lider

Proyectos interesantes

Proteomes-in-3D

Medical Technol...

Data Science

2M€ Cerrado

RYC2021-033994-I

Medical Technol...

Data Science

236K€ Cerrado

DECODINGSUMO

Medical Technol...

Data Science

2M€ Cerrado

BIO2008-00205

Medical Technol...

Data Science

269K€ Cerrado

nbPTMs

Medical Technol...

Data Science

2M€ Cerrado

SMPSBN

Medical Technol...

Data Science

188K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 59 meses Fecha Inicio: 2024-10-01
Fecha Fin: 2029-09-30

Líder del proyecto

RHEINISCHE FRIEDRICHWILHELMSUNIVERSITAT BONN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cellular behaviour is methodically studied using systems biology approaches that analyse the presence, absence, or oscillation of biomolecules. To this end, exogenous perturbations, among others, are used to alter protein expression and study their effects on cellular homeostasis. However, proteomes are inherently versatile and diversified by alternative splicing, protein cleavage, and post-translational modifications (PTM). Similarly, the spatiotemporal formation of multicomponent complexes plays an important but less well understood role in cellular homoeostasis and disorders. Specific recognition of these complexes by ligands is a difficult task to solve. Therefore, deciphering signalling cascades at the proteome and complex levels requires technologies that enable the identification of protein-binding and -inhibiting compounds that are sensitive or tolerant to PTMs and can recognize protein complexes. Intracellularly expressed aptamers, known as intramers, offer a solution to this challenge. The IntraMAP project will develop generally applicable paradigms for the automated evolution of intramers and combine them with cellular screening methods. In this way, intramers will be identified that are optimally adapted to cellular environments and effectively disrupt signalling cascades. These intramers will be used to identify signalling components and protein complexes associated with these cascades. They will be applied to various cells, organoids and in vivo to uncover fundamental principles of complex signalling events. The project has a strong interdisciplinary focus and will open novel avenues for the analysis of biomolecules. It has implications ranging from life sciences to systems biology, and will not only establish intramers as a broadly applicable discovery technology to study signalling cascades on an ‘omics’-like scale, but also holds enormous innovative potential for the development of novel gene therapies and future RNA-based drugs.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores