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Cell-Lasers

Financiado

Intracellular lasers Coupling of optical resonances with biological processes

Recently, micro-sized lasers have been integrated into biological systems including cells and tissues. Currently the most frequently used techniques to study complex processes in live cells employ fluorescent probes. However, fluo... ver más

31/10/2025

JSI

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

INSTITUT JOZEF STEFAN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-10-04

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2019-STG: ERC Starting Grant

I+D

Cerrada hace 6 años

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3 Participantes

JSI

1.08M€ | Lider

GENDIAG.EXE

1.44M€ | Participante

CENTER OF EXCELLENCE ON NANO...

413.07K€ | Participante

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 72 meses Fecha Inicio: 2019-10-04
Fecha Fin: 2025-10-31

Líder del proyecto

INSTITUT JOZEF STEFAN

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto Recently, micro-sized lasers have been integrated into biological systems including cells and tissues. Currently the most frequently used techniques to study complex processes in live cells employ fluorescent probes. However, fluorescent probes have several disadvantages including photobleaching, sensitivity to environmental factors, potential phototoxicity and broad emission spectrum, which limits their sensitivity, multiplexing ability and imaging capabilities in biological tissues. The transition from detecting laser emission from bio-integrated lasers instead of fluorescence represents a paradigm shift. Due to narrow emission linewidth, high coherence, large intensity and highly nonlinear output from lasers, they open huge opportunities in ultrasensitive sensing, spectral multiplexing and microscopy. The applicant has recently for the first time demonstrated a laser completely embedded inside a live human cell. However, to date it has only been demonstrated that laser light can be generated within the cell, but not how is the laser output coupled to the biophysical and biochemical processes inside cells. The goal of Cell-Lasers is to study these intimate interactions including forces acting within cells, properties of natural cavities in lipid droplets and the intracellular chemical environment. Since the spectral positions of laser lines do not change with propagation through scattering and absorbing media, the cell lasers will enable multiplexed sensing, tracking and localization of cells embedded deep inside tissues. In the long term Cell-Lasers aims to transform the bio-integrated lasers from being a pure scientific curiosity into powerful tool for the study of biophysical and biochemical processes taking place on a single cell level.

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