Integrated Structural and Probabilistic Approaches for Biological and Epidemiolo...
Integrated Structural and Probabilistic Approaches for Biological and Epidemiological Systems
Systems in nature are extremely robust, despite huge uncertainties and variability. Studying their nonlinear dynamic behaviour is challenging, due to their complexity and the many parameters at play, but crucial to understand impo...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
FIS2017-87519-P
ABORDANDO LA COMPLEJIDAD DE SISTEMAS SOCIOTECNICOS, BIOLOGIC...
169K€
Cerrado
PGC2018-094754-B-C21
ESTUDIO DE DINAMICAS NO LINEALES EN REDES COMPLEJAS MULTICAP...
105K€
Cerrado
NLNET-DYN
Towards a comprehensive mathematical description of the Dyna...
119K€
Cerrado
PGC2018-094754-B-C22
ESTUDIO DE DINAMICAS NO LINEALES EN REDES COMPLEJAS MULTICAP...
73K€
Cerrado
FIS2013-40653-P
DINAMICA NO LINEAL DE SISTEMAS COMPLEJOS
54K€
Cerrado
BES-2015-072438
SOCIOBIOTEC: FISICA ESTADISITCA Y NO LINEAL APLICADA A SISTE...
93K€
Cerrado
Información proyecto INSPIRE
Duración del proyecto: 59 meses
Fecha Inicio: 2023-01-01
Fecha Fin: 2027-12-31
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Systems in nature are extremely robust, despite huge uncertainties and variability. Studying their nonlinear dynamic behaviour is challenging, due to their complexity and the many parameters at play, but crucial to understand important phenomena, such as cellular dynamics, onset of diseases, epidemic spreading.Parameter-dependent simulations can predict the behaviour of natural systems case by case. Yet, the exact models and parameter values are poorly known, while qualitative behaviours are often preserved even with huge parameter variations, because they rely on the system interconnection structure. Parameter-free structural approaches can check whether a property is preserved for a whole family of uncertain systems exclusively due to its structure. However, when an expected property fails to hold structurally, novel approaches are needed to understand why, which system features prevent it, which key parameters must be finely tuned to enforce it.INSPIRE will develop a unifying framework to analyse and control families of uncertain dynamical systems in biology and epidemiology, which integrates for the first time structural, robust and probabilistic methods, tailored to the peculiarities of natural systems.The project will provide: i) methodologies to assess (practically) structural properties and unveil the mechanisms that enable/prevent a property, identifying the key parameters or motifs; ii) control paradigms that leverage such an insight to guarantee a desired global property through targeted local interventions; iii) scaling and aggregation approaches that exploit the properties of subsystems to mitigate computational complexity.The project outcomes, a mathematical theory as well as algorithms to analyse and control complex uncertain systems in nature, will strongly support the analysis and design of biomolecular feedback systems with a desired behaviour, the identification of therapeutic targets, the prediction and control of epidemic phenomena.