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INPAROL

Financiado

Innovative Parabiotics for oral health

Oral diseases constitute an increased major public health burden. Alternative dental prevention and therapeutic approaches such as probiotics are gaining popularity, but partly due to these products being live bacteria their use h... ver más

09/05/2023

UNIVERSITY OF MALT...

148K€

Presupuesto del proyecto: 148K€

Líder del proyecto

UNIVERSITA TA MALTA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-05-09

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

WF-03-2020: Widening Fellowships

I+D

Cerrada hace 4 años

0% 100%

2 Participantes

UNIVERSITY OF MALTA

148.05K€ | Lider

LABORATORIO AGRAMA

193.65K€ | Participante

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Duración del proyecto: 24 meses Fecha Inicio: 2021-04-29
Fecha Fin: 2023-05-09

Líder del proyecto

UNIVERSITA TA MALTA

TRL 4-5

Presupuesto del proyecto 148K€

Descripción del proyecto Oral diseases constitute an increased major public health burden. Alternative dental prevention and therapeutic approaches such as probiotics are gaining popularity, but partly due to these products being live bacteria their use has not gained significant popularity in dentistry. Parabiotics in appropriate doses have been shown to induce health benefits in other medical fields but have only as yet been tested sparingly for dental use. INPAROL aims at producing innovative parabiotics through ultrasound technology from mixed strains of probiotics used in commercial products. INPARAOL probiotics’ effects will be assessed by antimicrobial testing against oral pathogens (single and mixed culture) and also following exposure to varied environmental conditions. Best performing parabiotics will be subjected to biofilm assays replicating oral conditions and toxicity assays, in vitro cell monolayers and in vivo zebrafish embryo models, will be performed. Finally, the molecular changes of changes to inflammatory mediators will be monitored with complex in vitro infection models. Overall, this is the first time parabiotics for oral health application will be produced with the proposed methods which makes this research so niche. My strong clinical and microbiology research background makes INPAROL an ideal fit. I will be joined by a strong supervisory team at the University of Malta consisting of a renowned microbiologist and co-supervised by a world-leader on innovative antimicrobial approaches from the Academic Medical Centre, Amsterdam. INPAROL affords an unprecedented opportunity to build on my expertise to kick-start an independent research path in oral health research.

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