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Know your enemy systematic discovery of Salmonella anti Phage Defences for the...

Know your enemy systematic discovery of Salmonella anti Phage Defences for the improved design of phage therapeutics Antimicrobial drug resistance is a serious global threat that make us to fear the return of the mortality rates from pre-penicillin times. A promising alternative to antibiotic drugs is the phage therapy, which is based in viruses... ver más

29/01/2023

FUNDACION JUAN CAN...

246K€

Presupuesto del proyecto: 246K€

Líder del proyecto

FUNDACION JUAN CANALEJO MARITIMO DE OZA Cooperacion a la mejora de la asistencia sanitaria en el ambito de gestion del hospital juan canalejo de la coruna, asi como la promocion de...

TRL 4-5 | 2M€

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-01-29

MSCA-IF-2018: Individual Fellowships

I+D

Cerrada hace 6 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

FUNDACION JUAN CANALEJO MARI...

245.73K€ | Lider

MASSACHUSETTS INSTITUTE OF T...

MIT

165.27K€ | Participante

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Duración del proyecto: 46 meses Fecha Inicio: 2019-03-27
Fecha Fin: 2023-01-29

Líder del proyecto

FUNDACION JUAN CANALEJO MARITIMO DE OZA Cooperacion a la mejora de la asistencia sanitaria en el ambito de gestion del hospital juan canalejo de la coruna, asi como la promocion de...

TRL 4-5 | 2M€

Presupuesto del proyecto 246K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Antimicrobial drug resistance is a serious global threat that make us to fear the return of the mortality rates from pre-penicillin times. A promising alternative to antibiotic drugs is the phage therapy, which is based in viruses that kill bacteria. The rational design of effective phage therapeutics requires a fundamental understanding of evolutionary co-adaptation of phages and bacteria. These co-adaptations have led to the development of multiple anti-phage defence systems in bacteria which modulate their susceptibility to be killed by phages at strain level. In this way, the study of the diversity and mechanisms of action of defence islands in bacterial pathogens represents crucial knowledge for improving rapid delivery of phage-based therapeutics. The proposed work aims to deeply characterize the anti-phage defences in a human pathogen, Salmonella, to provide the strategy to discover and classify phage counter-defences for an optimal design of phage therapy. This project will characterize the genetics population of Salmonella to study the distribution and diversity of anti-phage defence islands and will validate the activity and function of the defence and counter-defence in bacteria and phage, respectively. The experienced researcher (ER) will establish a collaborative link between the laboratories of laboratories of Dr. German Bou (Spain), who has extensive experience in clinical microbiology and genetic modification methods, and Prof. Martin Polz (USA), who is a world expert in the ecology and evolution of environmental microbiology. This collaboration will allow to perform the most advanced methods in population and comparative genomics, isolation and discovery of phages, large scale phage host range assays and genetic modification of bacteria. The data generated in this project will be essential to understand the anti-phage defence mechanisms and to improve clinical decisions to maximize the efficacy of phage therapeutics.

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