Improving Peptide-Based Anti-Cancer Vaccines with Phosphatase Inhibitors
Peptides have great potential for vaccines. Peptide-based vaccines aim to increase the population and activity of pathogen/cancer-recognizing T cells by administering antigenic peptides carrying epitopes for major histocompatibili...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
KineTic
New Reagents for Quantifying the Routing and Kinetics of T c...
2M€
Cerrado
THERAVAC
Development of a therapeutic HPV vaccine via target epitope...
100K€
Cerrado
DCanVAX
A novel immuno-oncolytic virus-based dendritic cell therapeu...
Cerrado
MIMIC
Molecular mimicry as a key parameter shaping T cell immunity
2M€
Cerrado
DynOMIS
Dynamic Origins of MHC class I Selector function
195K€
Cerrado
NEWCARBOVAX
New generation of carbohydrate based vaccines via rational u...
244K€
Cerrado
Información proyecto PhosPepPres
Duración del proyecto: 21 meses
Fecha Inicio: 2023-04-05
Fecha Fin: 2025-01-31
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Peptides have great potential for vaccines. Peptide-based vaccines aim to increase the population and activity of pathogen/cancer-recognizing T cells by administering antigenic peptides carrying epitopes for major histocompatibility (MHC) class I and II. These peptides are endocytosed by dendritic cells (DCs), followed by intracellular proteolytic processing to release the epitopes, the loading of the epitopes on MHC, and finally the presentation to antigen-specific T cells. Despite numerous studies showing immunogenicity in preclinical settings, peptide-based vaccines have failed to show efficacy in clinical trials. One reason for this limited efficacy is that too low amounts of epitopes are presented on MHC. Thus, one way to improve peptide-based vaccines is to improve their intracellular processing for MHC presentation by DCs. In this project, we will explore a novel approach for increasing the cross-presentation efficiency. Moreover, we will perform pre-commercialization studies aimed at protecting the intellectual property, defining the commercialization strategy, and enhancing our industrial network. We expect that our strategy will raise interest, as many pharmaceutical companies are developing peptide-based vaccines.