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PLANTPEPTIDOMICS

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Cerrado

Identification isolation and characterization of novel pharmaceutically active...

Identification isolation and characterization of novel pharmaceutically active cysteine rich peptides from plants Natural products represent a pool of privileged structures that are optimized by evolution to interact with proteins and other biomolecules. The enormous structural diversity of natural products thus provides an indispensable reso... ver más

30/11/2013

UNIVIE

45K€

Presupuesto del proyecto: 45K€

Líder del proyecto

UNIVERSITAT WIEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2013-11-30 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIVIE

0.00€ | Lider

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Líder del proyecto

UNIVERSITAT WIEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 45K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Natural products represent a pool of privileged structures that are optimized by evolution to interact with proteins and other biomolecules. The enormous structural diversity of natural products thus provides an indispensable resource in an effective search for new therapeutic agents. Plants are of particular interest as source of pharmaceutically active compounds since they are used to treat diseases and maintain health since prehistoric times. They produce an enormous variety of substances that play a role in the plant defense mechanisms against predation by microorganisms, insects, and herbivores. The classical phytochemical approach in drug discovery focuses on secondary metabolites such as glycosides, phenolics, carbohydrates, alkaloids and terpenoids. The therapeutic potential of plant peptides and proteins, on the other hand, is by far less well studied and has only recently gained broader interest. The main reason for this is that standard proteomic and metabolomic approaches are not suitable for a systematic peptide analysis. For that reason, we are aiming at developing a peptidomic workflow using ultra-high performance chromatography and state-of-the-art mass spectrometry to cover the mass range of interest for the detection of plant peptides. The focus of the proposed project is the identification, isolation and characterisation of novel pharmacologically active peptides and mini-proteins from different plant species. Of particular interest are small (less than 100 amino acid residues), cysteine-rich peptides and proteins (CRPs), and in particular cyclotides, that often show remarkable antimicrobial, antifungal, antiviral and insecticidal activity as well as other pharmacologically interesting effects.

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