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DirectThalamus

Financiado

How the human thalamus guides navigation and memory a common coding framework b...

How the human thalamus guides navigation and memory a common coding framework built on direct thalamic recordings The thalamus is the major gateway for sensory input to the brain, and, as such, has long been thought of as a mere sensory relay station. But accumulating evidence suggests that it is crucially involved in higher cognitive functio... ver más

31/01/2025

LMU MUENCHEN

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

LUDWIGMAXIMILIANSUNIVERSITAET MUENCHEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-01-29

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2018-STG: ERC Starting Grant

I+D

Cerrada hace 7 años

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2 Participantes

LMU MUENCHEN

1.50M€ | Lider

INVESTIGACIONES Y APLICACION...

284.83K€ | Participante

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 72 meses Fecha Inicio: 2019-01-29
Fecha Fin: 2025-01-31

Líder del proyecto

LUDWIGMAXIMILIANSUNIVERSITAET MUENCHEN

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto The thalamus is the major gateway for sensory input to the brain, and, as such, has long been thought of as a mere sensory relay station. But accumulating evidence suggests that it is crucially involved in higher cognitive functions like memory formation and navigation. However, methodological obstacles still impede full understanding of the specific role of thalamus in human cognition. The core objective of DirectThalamus is to provide an advanced oscillatory model of subcortical processing as the neuronal basis of core cognitive functions. To this end, the project will address several key questions with the aim to identify and understand neuronal processing in the thalamus involved in human cognition: How does the human thalamus code and communicate information? And how does this contribute to spatial navigation and the formation and consolidation of memories? Using my unique expertise in innovative methodologies, I will exploit the rare opportunity to record and modulate intracranial electrophysiological activity in the human anterior thalamus. Together with intracranial recordings from the human hippocampus and comparative fMRI data from healthy subjects, these data will be used to test and establish a common coding framework for memory and navigation, highlighting contextual information processing as fundamental thalamic function. By directly recording and stimulating intracranial thalamic activity, DirectThalamus will provide novel and causal insight into thalamic mechanisms underlying core cognitive functions. The project will thereby push the boundaries of the state of the art in cognitive neuroscience towards a comprehensive understanding of cognition. Expanding the prevalent corticocentric focus on cognition to subcortical contributions will inspire new lines of research in fundamental and clinical neuroscience.

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