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Circuit elements of the cortical circuit for predictive processing
One promising theoretical framework to explain the function of cortex is predictive processing. It postulates that cortex functions by maintaining an internal model, or internal representation, of the world through a comparison of...
One promising theoretical framework to explain the function of cortex is predictive processing. It postulates that cortex functions by maintaining an internal model, or internal representation, of the world through a comparison of predictions based on this internal model with incoming sensory information. Implementing predictive processing in a cortical circuit would require a set of distinct functional cell types. These would include neurons that compute a difference between top-down predictions and bottom-up input, referred to as prediction error neurons, and a separate population of neurons that integrate the output of prediction error neurons to maintain an internal representation of the world. This research proposal will test the framework of predictive processing and identify different putative circuit elements and cell types that are thought to form the circuit in mouse visual cortex. We will use a combination of physiological recordings, optogenetic manipulations of neural activity, and gene expression measurements to determine the cell types that have functional responses consistent with different prediction errors, as well as those coding for the internal representation. Identifying the circuit elements underlying predictive processing in cortex may reveal a strategy to bias processing either towards top-down or bottom-up drive when the balance between the two is perturbed, as may be the case in neuropsychiatric disorders.
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Duración del proyecto: 60 meses
Fecha Inicio: 2020-01-16
Fecha Fin: 2025-01-31
Fecha Fin: 2025-01-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2020-01-16
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2019-COG:
ERC Consolidator Grant
Cerrada
hace 5 años
Presupuesto
El presupuesto total del proyecto asciende a
2M€
Líder del proyecto
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL R...
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
449.67K€ |
Participante