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HIV HOST FACTORS

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HOST FACTORS THAT FACILITATE AND RESTRICT HIV 1 REPLICATION

The efficient replication and spread of the Human Immunodeficiency Virus type 1 (HIV-1), the causative agent of the AIDS pandemic, requires that it parasitize an array of cellular proteins, many of which are unknown or uncharacter... ver más

30/11/2016

KINGS COLLEGE LOND...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

KINGS COLLEGE LONDON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-11-30 No tenemos la información de la convocatoria

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KINGS COLLEGE LONDON

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Líder del proyecto

KINGS COLLEGE LONDON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The efficient replication and spread of the Human Immunodeficiency Virus type 1 (HIV-1), the causative agent of the AIDS pandemic, requires that it parasitize an array of cellular proteins, many of which are unknown or uncharacterized, to facilitate its replication. In addition the virus must also defeat or subvert the human immune defences arrayed against it. Some of these immune defences, the innate retroviral restriction factors, have the capacity not only to directly interfere with the replication of the virus, but potentially to relay the information of its presence to activate a wider immune response – so called innate immune ‘sensing’. Molecular characterization of these processes for in vitro and in vivo replication of HIV-1 are essential for our understanding of the pathogenesis of HIV/AIDS. Additionally, it will provide strategies for the development of novel therapeutics for HIV treatment, and also potentially provide new paradigms that are applicable to other pathogenic mammalian viruses. To fill these gaps in our understanding this application seeks 5 years of ERC Starter Grant funding to explore two major research aims. Firstly we propose to characterize the interactions of retroviral restriction factors with the wider systemic immune response focusing on Tetherin/CD317/BST2 as a model system. In particular we will build on preliminary data suggesting that Tetherin can act as a general pattern recognition molecule for sensing assembling enveloped viruses by: A) transducing a proinflammatory signal and B) targeting nascent viral particles for antigen processing and presentation. Secondly we will apply novel genetic methods based on a haploid human cell line to identify, isolate and characterize human proteins that are required for early post-entry events in HIV replication or the function of the viral accessory protein Vpu.

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