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HIPODERM

Financiado

Cerrado

High Potency Dermatologicals

The HIPODERM application seeks support under the Marie Curie Industry-Academia Partnerships and Pathways scheme to facilitate the growth of a dynamic research team for 'the development of novel dermal-translocation, high-potency d... ver más

28/02/2015

WIT

838K€

Presupuesto del proyecto: 838K€

Líder del proyecto

WATERFORD INSTITUTE OF TECHNOLOGY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 3 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-02-28 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

WIT

0.00€ | Lider

CARDIFF UNIVERSITY

N.D. | Participante

EirGen

199.99K€ | Participante

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Líder del proyecto

WATERFORD INSTITUTE OF TECHNOLOGY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 838K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The HIPODERM application seeks support under the Marie Curie Industry-Academia Partnerships and Pathways scheme to facilitate the growth of a dynamic research team for 'the development of novel dermal-translocation, high-potency drug delivery systems'. Our aim is to develop a core scientific platform from which novel non-invasive drug delivery systems can be developed and clinically assessed. At the core of this project lies the hypothesis that microneedle assisted topical drug delivery has failed to fulfil expectations because researchers have routinely over estimated the scale of permeation enhancement possible using passive microneedle treatment and also, in general, have targeted unsuitable therapeutic molecules. This project aims to address both of these issues by developing new formulation and fabrication approaches. Combining physical disruption of the stratum corneum barrier with microneedle arrays and a number of active permeation enhancement techniques (such as iontophoresis and phonophoresis) will produce a range of novel hybrid permeation enhancement systems (HPES). The project will focus on high potency therapeutics possessing low therapeutic concentrations that make only realistic demands on delivery systems. Such high potency materials are of increasing importance in therapeutics but are inherently difficult to work with because of the health and safety implications of their high activity. The project pools the expertise of a number of international partners with particular expertise in specific aspects of the approach. Three clinically interesting target areas have been identified for evaluation: 1. Locally delivered chemotherapeutic agents for the treatment of cancers of the skin and underlying tissues 2. Enhanced localised delivery of potent photosensitisers for photodynamic therapy (PDT) 3. Local and systemic delivery of therapeutic peptides

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