Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

HCA Organoid

Financiado

Cerrado

HCA Organoid Pilot action to establish a multi tissue human organoid platform w...

HCA Organoid Pilot action to establish a multi tissue human organoid platform within the Human Cell Atlas as a booster of future disease centric mechanistic and translational research "Excellence: The Human Cell Atlas (HCA) is descriptive by definition, as it seeks to map all cells in the human body. Yet its goal of understanding fundamental human biological processes and diagnosing, monitoring, and treating di... ver más

30/09/2022

CEMM FORSCHUNGSZE...

5M€

Presupuesto del proyecto: 5M€

Líder del proyecto

CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZ... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 8 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-09-30

SC1-BHC-31-2019: Pilot actions to build the foundati...

I+D

Cerrada hace 5 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

8 Participantes

CEMM FORSCHUNGSZENTRUM FUER...

1.11M€ | Lider

GERMAN CANCER RESEARCH CENTE...

809.25K€ | Participante

PrinsesMaximaCentrumvoorKind...

923.13K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

OrganoidAlign Comparative modelling of organoids in the age of single cell... 213K€ Cerrado

ORGESTRA Organoid technologies for disease modeling, drug discovery a... 3M€ Cerrado

PTA2023-022862-I Servicio en cultivos celulares pluripotentes, análisis y cri... 52K€ Cerrado

LifeTime Revolutionizing Healthcare by Tracking and Understanding Hum... 1M€ Cerrado

CNS2023-145726 Herramientas diagnósticas, pronósticas y terapéuticas 200K€ Cerrado

ReprOids Reprogramming of somatic cells into organOids: patient-centr... 3M€ Cerrado

Duración del proyecto: 34 meses Fecha Inicio: 2019-11-24
Fecha Fin: 2022-09-30

Líder del proyecto

CEMM FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZ... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 5M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "Excellence: The Human Cell Atlas (HCA) is descriptive by definition, as it seeks to map all cells in the human body. Yet its goal of understanding fundamental human biological processes and diagnosing, monitoring, and treating disease (HCA Whitepaper) depends on our ability to draw functional/causal/mechanistic conclusions relevant to human diseases. Personalized organoid technology aptly fills this gap, as it makes human tissue amenable to functional studies and faithful disease modeling in vitro. This project will firmly establish a ""Human Organoid Atlas"" within the HCA. Initially focusing on two organs (colon and brain: 100 distinct organoid lines each). We will establish single-cell transcriptomes, single-cell epigenomes, and time-series imaging for several thousand organoids and matched primary tissue. This resource will primarily quantify normal population variation and provide a baseline for disease studies. Moreover, the project will include data generation and analysis of >20 colorectal cancer organoid lines with matching organoid lines derived from normal (healthy) material as well as the respective matching primary tissue. We will show the practical utility of the resource by proof-of-concept disease modeling for genetic epilepsy (brain) and large-scale characterization of disease-linked genetic variants (colon). Impact: 1. Deeply characterized organoid collection enables functional and disease-centric studies pursuing HCA insights. 2. Single-cell dataset provides reference of population variation under highly standardized conditions. 3. Linking single-cell profiling and organoids will boost HCA’s impact on human health. Implementation: The project connects the European founders of organoid research (Hans Clevers, Jürgen Knoblich) with expertise in large-scale epigenome/transcriptome profiling (Christoph Bock, Henk Stunnenberg), advanced imaging (Prisca Liberali, Anne Rios), bioinformatics and systems genetics (Oliver Stegle, Michael Boutros), data management (Laura Clarke/EBI), and strong SME contribution (Hubrecht Organoid Technology, Eurice). The project is fully committed to the HCA's values. It implements extensive data sharing and sustainability measures."

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores