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GOOD OR BAD BUGS

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GOOD OR BAD BUGS FRIEND OR FOES UNRAVELING DIFFERENCES BETWEEN MUTUALISM AND P...

GOOD OR BAD BUGS FRIEND OR FOES UNRAVELING DIFFERENCES BETWEEN MUTUALISM AND PATHOGENICITY IN BURKHOLDERIA SPECIES """What better microbial challenge to unite agricultural and medical microbiologists than a microoorganism that reduces an onion to a macerated pulp, protects crops from diseases, devastates the health and social life of cystic fi... ver más

31/08/2023

UZH

191K€

Presupuesto del proyecto: 191K€

Líder del proyecto

UNIVERSITAT ZURICH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-08-31

MSCA-IF-2019: Individual Fellowships

I+D

Cerrada hace 5 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

UZH

191.15K€ | Lider

DINAMICA DRIVE SOLUTIONS

385.09K€ | Participante

GONVARRI I CENTRO DE SERVICI...

359.61K€ | Participante

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Duración del proyecto: 40 meses Fecha Inicio: 2020-04-06
Fecha Fin: 2023-08-31

Líder del proyecto

UNIVERSITAT ZURICH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 191K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto """What better microbial challenge to unite agricultural and medical microbiologists than a microoorganism that reduces an onion to a macerated pulp, protects crops from diseases, devastates the health and social life of cystic fibrosis patients, and not only is resistant to the most famous antibiotic, penicillin, but can use it as a nutrient!"". The genus Burkholderia accommodates around 120 species that colonize a wide range of ecological niches and interact with hosts in different ways such as mutualism, commensalism or pathogenicity. Opportunistic pathogens like B. cenocepacia cause severe infections in cystic fibrosis and immunocompromised patients, and mutualists such as B. phytofirmans are beneficial to plants. Although very promising for agriculture, the use of the latter is severely restrained due to the potential threat that a few opportunistic pathogenic strains pose to human health. In the last years, a lot of effort has been invested into discriminating between the beneficial and the pathogenic strains. However, these studies have been unsuccessful so far and novel approaches are needed to better understand the potential risks/benefits associated to Burkholderia species before these can keep being used in agriculture. Friends or foes? The GOOD OR BAD BUGS project aims to unravel the dissimilarities between the beneficial (the good) and the pathogenic (the bad) Burkholderia species. We hypothesize that differences in the genomes of the Burkholderia species allow them to colonize and interact with their host differently, leading to mutualism, commensalism or pathogenicity. In this project we will employ a cutting-edge high-throughput genetic screening method known as transposon-sequencing to study host colonization by members of the genus Burkholderia. This promising methodology will help to identify genes that provide a fitness in a particular environment. The outcome of the project will be of interest both at the agriculture and the medicine levels."

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