Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

AU-DOUBLEC-H

Financiado

Cerrado

Gold catalysed dehydrogenative cross coupling of arenes

The usually inert carbon-hydrogen (C-H) bond is present in nearly all synthetic and naturally occurring organic molecules. The modification of organic compounds through the direct functionalisation of C-H bonds is however a highly... ver más

31/03/2016

UNIVERSITY OF MANC...

222K€

Presupuesto del proyecto: 222K€

Líder del proyecto

THE UNIVERSITY OF MANCHESTER No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-03-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UNIVERSITY OF MANCHESTER

0.00€ | Lider

QMUL

N.D. | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

2O2ACTIVATION Development of Direct Dehydrogenative Couplings mediated by... 1M€ Cerrado

CTQ2011-28258 CATALISIS ORGANOMETALICA: FUNCIONALIZACION DE ENLACES C-H 240K€ Cerrado

CTQ2017-88451-R GENERACION NO CONVENCIONAL DE REACTIVOS ORGANOMETALICOS CATA... 71K€ Cerrado

CTQ2009-13840 NUEVAS METODOLOGIAS SINTETICAS PARA LA FUNCIONALIZACION CATA... 93K€ Cerrado

CTQ2008-00810 REACCIONES DE ACTIVACION DE ENLACES C-H Y ACOPLAMIENTO C-C Y... 394K€ Cerrado

C-H ACTIVATION New Concepts for Utilizing a Ubiquitous Non Functional Gro... 1M€ Cerrado

Líder del proyecto

THE UNIVERSITY OF MANCHESTER No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 222K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The usually inert carbon-hydrogen (C-H) bond is present in nearly all synthetic and naturally occurring organic molecules. The modification of organic compounds through the direct functionalisation of C-H bonds is however a highly challenging process due to their poor reactivity and the difficulty of discriminating between the many C-H bonds present in most molecules. Nevertheless, catalytic C-H activation has emerged as an increasingly promising strategy for simple and atom-economical cross-coupling of organic compounds. Compared to current methodologies that require the use of pre-functionalized starting materials, the development of general and efficient catalytic C-H activation systems could significantly reduce the amount of waste generated in synthetic reactions by (1) using readily available starting materials (2) shortening reaction sequences and (3) avoiding the stoichiometric generation of metal salts default to synthesis that rely on the use of pre-functionalised building blocks. This project aims at the development of catalytic systems for the formation of biaryls by the direct coupling of two arenes via double C-H activation. Such arylations require the selective breaking of two distinct C-H bonds followed by the subsequent C-C bond formaton. We will make use of the unique ability of gold complexes to discriminate between C-H bonds in different electronic environments depending on the oxidation state of the gold catalyst. Thus, we will develop catalytic cross-coupling processes proceeding via (1) gold(I) mediated C-H activation of electron poor arenes, (2) oxidation of the catalyst to gold(III) followed by gold(III) mediated C-H activation of electron rich arenes, and (3) C-C bond formation furnishing biaryl compounds. The described proposal will significantly contribute to the current state of the art cross-coupling methodologies and offer a direct and green approach to the synthesis of biaryl motifs.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores