Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

FUNCTIONARCHITECTURE

Financiado

Cerrado

Functional implications of the remarkable conservation of eukaryotic gene archit...

Functional implications of the remarkable conservation of eukaryotic gene architecture One of the fundamental principles in comparative genomics is that evolutionary conservation implies functional importance. This principle has been used extensively in the life sciences, as a tool to detect biological functionality... ver más

31/12/2013

THE HEBREW UNIVERS...

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

THE HEBREW UNIVERSITY OF JERUSALEM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2013-12-31 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

THE HEBREW UNIVERSITY OF JER...

0.00€ | Lider

Proyectos interesantes

PHYGENOM

Data Science

Applied Physics

995K€ Cerrado

RYC2020-028685-I

Data Science

Applied Physics

324K€ Cerrado

EINME

Data Science

Applied Physics

1M€ Cerrado

BFU2014-55062-P

Bioinformatics

Data Science

194K€ Cerrado

FUNCSPECGEN

Data Science

Applied Physics

1M€ Cerrado

RETVOLUTION

Data Science

Applied Physics

2M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

THE HEBREW UNIVERSITY OF JERUSALEM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto One of the fundamental principles in comparative genomics is that evolutionary conservation implies functional importance. This principle has been used extensively in the life sciences, as a tool to detect biological functionality. In the vast majority of studies, evolutionary conservation has been sought in three biological entities: sequence (actual nucleotide or amino-acid sequences, as well as sequence properties like codon usage bias, GC content, and amino-acid bias); structure (like RNA, DNA and protein secondary and tertiary structures); and genome architecture (like synteny, gene order, relative gene orientation). These strategies have worked very well, but evidence is rapidly accumulating that there is a lot of function without detectable conservation. Many factors can potentially contribute to such undetected functionality, such as functions that do not depend on sequence or structure (for instance, nonsense mediated decay is affected by the mere location of the introns), functions that depend on very short and redundant sequence motifs, co-evolution of factor and target, and migration of functional sequences along the chromosome. We suggest a novel strategy to identify parts of these undetected functions. We study how to quantify the conservation in a fourth type of biological entity, that we dub gene architecture, and which is derived from the exon-intron structure of the gene. To this end, we are building a eukaryotic gene architecture database, and developing an algorithm to quantitatively evaluate the level of architectonic conservation in the different regions of the gene. Preliminary analysis reveals that conservation of gene architecture is plentiful, and in many cases it can be detected over very long evolutionary times (more than a billion years). This allows us to identify genic elements, mostly introns and splice junctions, which are likely to be of functional importance.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores