Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

AUTOIMMUNITY RASGRP1

Financiado

Cerrado

Functional analysis of RasGRP1 SNPs in autoimmune disease

Autoimmunity is caused by chronic inflammation mediated by T- and B-lymphocytes. Thus far, treatment of autoimmunity consists of general immune suppressants, causing unwarranted side effects, without curing disease. Therefore, the... ver más

15/01/2017

UMC UTRECHT

260K€

Presupuesto del proyecto: 260K€

Líder del proyecto

UNIVERSITAIR MEDISCH CENTRUM UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2017-01-15 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UMC UTRECHT

0.00€ | Lider

Proyectos interesantes

SAF2016-74891-R

Medical Technol...

Data Science

109K€ Cerrado

RIISPAD

Medical Technol...

Data Science

100K€ Cerrado

M-Imm

Medical Technol...

Immunology

2M€ Cerrado

SAF2011-29635

Medical Technol...

Data Science

206K€ Cerrado

RC3H1/2-SPECIFICITY

Medical Technol...

Data Science

1M€ Cerrado

SAF2016-78631-P

Medical Technol...

Data Science

278K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

UNIVERSITAIR MEDISCH CENTRUM UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 260K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Autoimmunity is caused by chronic inflammation mediated by T- and B-lymphocytes. Thus far, treatment of autoimmunity consists of general immune suppressants, causing unwarranted side effects, without curing disease. Therefore, the need for a specific treatment targeting the cause of disease is growing. In this fellowship will focus on elucidating how SNPs (single nucleotide polymorphisms) in RasGRP1 play a role in aberrant lymphocyte activity in patients with autoimmunity. RasGRP1 is critical in the activation of Ras, resulting in lymphocyte activation. Preliminary data show that a point mutation in Rasgrp1, Rasgrp1Anaef, results in autoimmunity in mice, characterized by anti-nuclear antibodies and activated CD4+ T cells. Moreover, Rasgrp1Anaef/wildtype heterozygote mice show a similar phenotype, arguing that one wildtype allele cannot compensate for the Rasgrp1Anaef allele. We have established that hypomorphic Rasgrp1 variants can exert a dominant negative effect, which relies on coiled-coil mediated dimerization with wildtype Rasgrp1. This new concept of RasGRP1 dimerization, suggests that monoallelic, non-synonymous RasGRP1 variants may affect the activity of a RasGRP1 dimer in patients. In the proposed fellowship, I will: (1) Model non-synonymous SNPs in patients to our structure of RasGRP1 and test the functional effect, (2) Establish how dimerization affects RasGRP1 function, and (3) Establish if RasGRP1 signaling is aberrant in lymphocytes of patients. This will help us understand how autoimmunity comes about, and will provide new potential strategies for development of more specific therapies. I anticipate that these RasGRP1-centric studies will function as a paradigm for future studies on dysregulated signaling pathways in autoimmune T cells. This fellowship will put me in an excellent position to start my independent research in Europe, introducing functional research of SNPs in key lymphocyte signaling molecules to the field of (pediatric) rheumatology.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores