Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MecaMorphEME

Financiado

Cerrado

Four dimensional physical modeling and numerical simulation of the early mouse e...

Four dimensional physical modeling and numerical simulation of the early mouse embryo morphogenesis. The quantitative understanding of the early development of mammalian embryos is essential to the progress of reproductive medicine. Yet, the physical and mechanical principles governing their morphogenesis remain largely unknown.... ver más

31/08/2017

EMBL

171K€

Presupuesto del proyecto: 171K€

Líder del proyecto

EUROPEAN MOLECULAR BIOLOGY LABORATORY No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2017-08-31

MSCA-IF-2014-EF: Marie Skłodowska-Curie Individual F...

I+D

Cerrada hace 10 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

EMBL

171.46K€ | Lider

Proyectos interesantes

BFU2011-29423

Medical Technol...

Applied Physics

467K€ Cerrado

DPI2013-43727-R

Medical Technol...

Applied Physics

48K€ Cerrado

Morphomechanics

Medical Technol...

Applied Physics

88K€ Cerrado

MechanoFate

Medical Technol...

Applied Physics

2M€ Cerrado

MECHABLASTO

Medical Technol...

Applied Physics

1M€ Cerrado

BFU2014-57019-P

Medical Technol...

Applied Physics

175K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 29 meses Fecha Inicio: 2015-03-17
Fecha Fin: 2017-08-31

Líder del proyecto

EUROPEAN MOLECULAR BIOLOGY LABORATORY No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 171K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The quantitative understanding of the early development of mammalian embryos is essential to the progress of reproductive medicine. Yet, the physical and mechanical principles governing their morphogenesis remain largely unknown. Early mouse embryos self-organize by a succession of cell divisions, deformations and rearrangements, leading ultimately to the specification of two distinct cell lineages, segregated in inside and outside layers. Mechanical forces are therefore as important as biochemical activity in this process and precise 4-dimensional imaging of cells within the embryo reveals intense surface dynamics, regulated by contractile and adhesion proteins. However, our understanding of early embryos development still lacks a precise physical model integrating a dynamic description of the mechanical forces controlling cell shape and cell-cell adhesion. I will design a 4D physical model of the early mouse embryo providing accurate cell dynamics predictions. Cell shapes are primarily controlled by the actomyosin cortex and they will be described using recently developed cortical active shell theories. To represent accurately cell-cell adhesion dynamics, I will consider the crosstalk between cortical and adhesion proteins activities. Importantly, this model will be designed in close collaboration with an experimental group expert in the biophysical characterization of the mouse embryo, to incorporate measured mechanical parameters and molecular regulation mechanisms. Our model will be refined through cycles of theoretical predictions and experimental validations to uncover the principles of early mammalian embryos development and, more specifically, the mechanism of cell internalization at the 8 to 16 cells transition. This interdisciplinary project, at the interface between physical modeling and developmental biology will provide a unique and accurate biophysical framework for understanding the morphogenesis of early mammalian embryos.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores