Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

Morphomechanics

Financiado

Cerrado

Emergence of tissue mechanical properties from molecular and cellular activity d...

Emergence of tissue mechanical properties from molecular and cellular activity during morphogenesis Morphogenesis refers to the set of complex movements and deformations that tissues experience during development to give rise to the three dimensional form of organs and organisms. From a biomechanical perspective tissues represen... ver más

28/02/2015

CSIC

88K€

Presupuesto del proyecto: 88K€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-02-28 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CSIC

0.00€ | Lider

Proyectos interesantes

BFU2011-25828

Medical Technol...

Biomaterials

144K€ Cerrado

MechanoFate

Medical Technol...

Applied Physics

2M€ Cerrado

TIMORPH

Medical Technol...

Applied Physics

2M€ Cerrado

BFU2010-16546

Medical Technol...

Applied Physics

169K€ Cerrado

Self-Control

Medical Technol...

Applied Physics

3M€ Cerrado

MECHABLASTO

Medical Technol...

Applied Physics

1M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Presupuesto del proyecto 88K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Morphogenesis refers to the set of complex movements and deformations that tissues experience during development to give rise to the three dimensional form of organs and organisms. From a biomechanical perspective tissues represent a unique class of materials, which exhibit dynamic mechanical properties that evolve over time. Little is known about how these macroscopic properties arise from the interplay and integration of molecular, cellular and tissue events. In this project, I propose to use the process of Dorsal Closure of the Drosophila embryo to undertake a dynamic study of morphogenesis spanning the molecular, cellular and tissue levels, to obtain insights into how tissue properties emerge from the coordinated activity of its constituent cells. These studies will focus on the amnioserosa, one of the main force-generating tissues during DC that has proved to be a powerful system to study the emergence of morphogenetic forces. The focus of this project is to understand the molecular mechanisms underlying actomyosin activity, how they translate into effective cell shape changes and how this activity is coordinated across the whole tissue to give rise to the contractile activity of the tissue. For this, I will use a combination of classical genetics and state of the art microscope techniques to obtain quantitative information on the dynamic behaviour of molecules, sub-cellular modules and cells. I will investigate how molecular and cellular events impinge on the mechanical properties of the tissue, which will be probed by laser ablation experiments in wild type and in embryos with perturbed actomyosin dynamics. The multi-disciplinary research outlined in this project has the potential to make significant contributions to the young field of cell-developmental biology and the physical and engineering sciences.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores