Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

DisCharge

Financiado

Cerrado

Exploring molecular determinants of charged disordered protein interactions pha...

Exploring molecular determinants of charged disordered protein interactions phase separation and function from the test tube to the cell Biological molecular recognition is centred around the structure-function paradigm, involving interfacial complementary shapes and non-covalent forces. Intrinsically disordered proteins (IDPs), constituting up to 40% of the proteo... ver más

29/04/2024

UZH

191K€

Presupuesto del proyecto: 191K€

Líder del proyecto

UNIVERSITAT ZURICH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-04-29

MSCA-IF-2019: Individual Fellowships

I+D

Cerrada hace 5 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UZH

191.15K€ | Lider

RESET WORLD

697.79K€ | Participante

Proyectos interesantes

IDPro

Medical Technol...

Data Science

Cerrado

PID2021-127907NB-I00

Medical Technol...

Applied Physics

139K€ Cerrado

CTQ2014-52633-P

Medical Technol...

Data Science

218K€ Cerrado

IDPBYNMR

Medical Technol...

Data Science

3M€ Cerrado

FLINDIP

Medical Technol...

Data Science

213K€ Cerrado

CTQ2016-78636-P

Medical Technol...

Data Science

36K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 48 meses Fecha Inicio: 2020-04-16
Fecha Fin: 2024-04-29

Líder del proyecto

UNIVERSITAT ZURICH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 191K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Biological molecular recognition is centred around the structure-function paradigm, involving interfacial complementary shapes and non-covalent forces. Intrinsically disordered proteins (IDPs), constituting up to 40% of the proteome, evade the structure-function paradigm, owing to their lack of persistent structure. Despite some IDPs forming folded complexes, numerous IDPs form disordered complexes stabilized by multivalent interactions. An extreme example is the recently discovered disordered high-affinity complex formed by two highly charged IDPs, the nucleosome binding linker histone (H1) and its nuclear chaperone prothymosin-alpha (ProTa), both key regulators of chromatin-structure and -function. IDPs are also often implicated in liquid-liquid phase separation (LLPS) driven assemblies that facilitate numerous biochemical interactions. The specificity question in IDPs becomes particularly pertinent for such charge driven disordered interactions and associated LLPS processes considering the great abundance of such highly charged disordered stretches in our proteome. Specific physiological function of most IDP interactions and associated LLPS processes imply an important role of specificity, albeit encoded differently from folded proteins. Only a multidisciplinary study spanning several complexity regimes, which is currently lacking, can uncover such altered specificity. I hypothesize that physiologically, ProTa/H1 interaction plays out in LLPS-driven heterochromatin assemblies leading to transcriptional regulation. I will probe ProTa/H1 interactions and phase behaviour with a set of systematically designed variants in incrementally complex milieu, from the test-tube to the cell, to reveal how the sequence dictates interactions and phase behaviour in-vitro and attribute a given function in-cell. This will shed light on specificity determinants of interaction and function for such highly charged IDPs.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores