EmerVir
Financiado
Experimental assessment of wildlife viruses emergence potential through systemat...
Experimental assessment of wildlife viruses emergence potential through systematic characterization of human cell tropism
Emerging viruses pose a tremendous threat to human health and economy, as dramatically shown by the ongoing COVID-19 pandemic. Most emerging viruses are zoonotic, meaning that they can be transmitted between animal species and hum...
Emerging viruses pose a tremendous threat to human health and economy, as dramatically shown by the ongoing COVID-19 pandemic. Most emerging viruses are zoonotic, meaning that they can be transmitted between animal species and humans. Although it was estimated that more than one million viral species exist in the two main reservoirs of zoonotic viruses (mammals and birds), only a few hundred are known to infect humans. This means that the majority of wildlife viral species will likely not cause major outbreaks in the human population, but that many potentially human-infective viruses are lurking in nature. Although large-scale metagenomic studies allowed the identification of thousands of new viral species, functional data, including their ability to infect human cells, are often missing. Previous work has examined the human cell tropism of a fraction of wildlife viruses, but no systematic analysis of the factors involved in viral entry has been undertaken. In this proposal, we will use synthetic biology, experimental virology and viral evolution using a large number of human cell lines to implement a high throughput characterization of wildlife viruses' tropism. We will first test whether wildlife viruses’ envelopes from diverse viral families can mediate infection of a large panel of human cell lines. Comparing available transcriptomic data of susceptible and non-susceptible cell lines, we will identify novel wildlife viruses’ host entry factors. Finally, using experimental evolution, we will investigate how viral envelope natural selection and diversification impact the use of these newly identified entry determinants. Overall, this project should improve epidemic preparedness by identifying viral species or variants at higher risk to infect humans, as well as host factors participating to viral entry, which are potential targets for the development of antivirals.
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Duración del proyecto: 30 meses
Fecha Inicio: 2023-04-25
Fecha Fin: 2025-11-14
Fecha Fin: 2025-11-14
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-04-25
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2022-PF-01-01:
MSCA Postdoctoral Fellowships 2022
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
165K€
Líder del proyecto
UNIVERSITAT DE VALÈNCIA (ESTUDI GENERAL)
La universitat de valencia, como servicio publico que es, imparte las enseñanzas necesarias para la formacion de los estudiantes, la prepara...
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