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ROBOX

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Expanding the industrial use of Robust Oxidative Biocatalysts for the conversion...

Expanding the industrial use of Robust Oxidative Biocatalysts for the conversion and production of alcohols ROBOX Oxygen functionalities are key functional groups in many of today’s chemicals and materials. The efficient introduction of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Inno... ver más

31/03/2019

RIJKSUNIVERSITEIT...

11M€

Presupuesto del proyecto: 11M€

Líder del proyecto

RIJKSUNIVERSITEIT GRONINGEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-03-31

BIOTEC-3-2014: Widening industrial application of... Scope:Specific challenge: Biocatalysis is increasingly used in synthetic routes to complex molecules...

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25 Participantes

RIJKSUNIVERSITEIT GRONINGEN

1.06M€ | Lider

CEREALES Y TRANSPORTES BRAVO...

TECHNICAL UNIVERSITY OF DENM...

705.26K€ | Participante

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Duración del proyecto: 49 meses Fecha Inicio: 2015-02-11
Fecha Fin: 2019-03-31

Líder del proyecto

RIJKSUNIVERSITEIT GRONINGEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 11M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Oxygen functionalities are key functional groups in many of today’s chemicals and materials. The efficient introduction of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative bio-catalytic oxidation routes using molecular oxygen (from air) under benign and mild (pH) conditions such as ambient temperature and pressure can greatly improve the sustainability and economics of processes, but were so far mainly been applied in the pharma segments. In this segment, the enzyme-catalyzed step often represents the highest added value and the high price of the end-product (> €1000/kg) justifies less than optimal enzyme production and limitations in its catalytic efficiency. In order to achieve the widening of industrial application of enzymatic bio-oxidation processes to also larger volume but lower price chemical markets, ROBOX will demonstrate the techno-economic viability of bio-transformations of four types of robust oxidative enzymes: P450 monooxygenases (P450s), Baeyer-Villiger MonoOxygenase (BVMOs), Alcohol DeHydrogenase (ADH) and Alcohol OXidase (AOX) for which target reactions have already been validated on lab-scale in pharma, nutrition, fine & specialty chemicals and materials applications. ROBOX will demonstrate 11 target reactions on large scale for these markets in order to prepare them for scale up to commercial-scale plants. ROBOX is industry-driven with 2 major industrial players and 6 SME’s. It will assess the potential of technologies applied to become platform technologies technologies (multi-parameter screening systems, computational methodologies, plug bug expression systems) for broad replication throughout the chemical industry. The markets addressed within ROBOX represent a joint volume of over 6.000 ktons/year. The introduction of bio-oxidation processes is expected to bring substantial reductions in cost (up to -50%), energy use (-60%), chemicals (-16%) and GHG-emissions (-50%).

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