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EXOsomes as a new strategy in Assisted Reproductive Technologies tracing matern...

EXOsomes as a new strategy in Assisted Reproductive Technologies tracing maternal nanomessengers to improve pregnancy outcomes The current embryo in vitro culture conditions used in most laboratories of assisted reproductive technologies (ARTs) allow the embryo to develop to the blastocyst stage and to achieve pregnancy. However, the quality of those embr... ver más

31/08/2022

UZH

191K€

Presupuesto del proyecto: 191K€

Líder del proyecto

UNIVERSITAT ZURICH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-08-31

MSCA-IF-2019: Individual Fellowships

I+D

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2 Participantes

UZH

191.15K€ | Lider

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Duración del proyecto: 28 meses Fecha Inicio: 2020-04-14
Fecha Fin: 2022-08-31

Líder del proyecto

UNIVERSITAT ZURICH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 191K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The current embryo in vitro culture conditions used in most laboratories of assisted reproductive technologies (ARTs) allow the embryo to develop to the blastocyst stage and to achieve pregnancy. However, the quality of those embryos is suboptimal compared to the in vivo ones and the obtained pregnancy rates are low. The lack of maternal signals, during the in vitro period has been postulated as a main reason for these suboptimal results. There is increasing evidence of the role of the oviduct exosomes (oEXs) as mediators of the early maternal-cross talk. Recent data revealed the first oviduct-derived EXs protein signature and their important roles in embryo-oviduct interactions. In the present proposal, using bovine model, we aimed to: (i) Evaluate whether the presence of the early embryo in the oviduct could modulate the oEXs proteins, mRNA and miRNA content depending on its stage of development. (ii) Assess whether the embryo quality (good or poor embryo) affect the content of EXs secreted in vitro by the oviduct epithelial cells. (ii) Assess the effect of in vitro culture with oEXs on the embryo development and quality. To accomplish these tasks, an ambitious, realistic, work plan has been designed based on the excellent background of the Fellow, and the training she will receive, the expertise of the supervisor in female reproductive physiology and the infrastructure within the host lab for conducing all the experiments with most appropriate tools. This will ensure that the Fellow completes the scientific objectives of the proposal, communicate and disseminate the results to the scientific and public, while acquiring new set of skills that will have an important impact in her career development. If the beneficial effect of oEXs on embryo development is recapitulated in cattle, it could improve in vitro embryo production largely used in ART in dairy cattle industries. Moreover, the obtained results may be transferred in human species

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