Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

DEFCOMANT

Financiado

Cerrado

Establishing defined communities of Antarctic soil bacteria as potential sources...

Establishing defined communities of Antarctic soil bacteria as potential sources of antimicrobials The discovery of antibiotics is one of the greatest achievements in human medicine. However, the introduction and overuse of antibiotics led towards selection of multidrug-resistant bacterial pathogens that are one of the major co... ver más

31/12/2023

UNIVIE

174K€

Presupuesto del proyecto: 174K€

Líder del proyecto

UNIVERSITAT WIEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-12-31

MSCA-IF-2020: Individual Fellowships

I+D

Cerrada hace 4 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIVIE

174.17K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

NAfrAM Novel antibiotics from Antarctic microbes 190K€ Cerrado

SAF2010-15010 DESCUBRIMIENTO Y CARACTERIZACION DE NUEVOS ANTIBIOTICOS MEDI... 206K€ Cerrado

ARISE The Ecology of Antibiotic Resistance 2M€ Cerrado

NEXTER Next generation eco friendly microbiome preserving and redu... 150K€ Cerrado

CaLiAT A novel pathway for generation of building blocks for antibi... 195K€ Cerrado

BACtheWINNER Bacteriocins from interbacterial warfare as antibiotic alter... 3M€ Cerrado

Duración del proyecto: 33 meses Fecha Inicio: 2021-03-30
Fecha Fin: 2023-12-31

Líder del proyecto

UNIVERSITAT WIEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 174K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The discovery of antibiotics is one of the greatest achievements in human medicine. However, the introduction and overuse of antibiotics led towards selection of multidrug-resistant bacterial pathogens that are one of the major concerns of modern medicine. Novel antibiotic classes are the most promising way to overcome current antibiotic resistance. To achieve this goal, antibacterial drug development is re-focused once again on natural products, especially by sourcing not-yet-explored or underexplored environments that represent a rich source of potentially bioactive microorganisms. One of such unique and intact environments is Antarctica with surprisingly high microbial biodiversity. The Antarctic soil microbiome has been proven as a rich reservoir of biosynthetically active bacteria with potential to produce novel antimicrobial molecules. However, simple exploration for antimicrobials among isolated microorganisms has its limitation, one of which is supressed expression of biosynthetic genes in laboratory conditions. The aim of the proposed project is to search for antimicrobial metabolites among unique Antarctic isolates and to streamline the process through a novel approach. Biosynthetic potential of isolates will be firstly characterized through genomics to identify the most promising strains. Afterwards, a novel tool, co-cultivation combined with high advanced omics methods will be implemented to design and grow well-defined microbial communities. Mutual microbial interactions in communities will stimulate metabolic activities of individual strains and expression of otherwise ‘silent’ genes resulting in production of various compounds, some of which may express antimicrobial activities. This project will result in establishment of the first defined Antarctic microbiotas and access their full biosynthetic potential to produce bioactive compounds, especially those active against the most critical multidrug-resistant bacterial pathogens in human healthcare.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores