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EMC-FLU

Financiado

Epithelial-mesenchymal crosstalk in the pathology of influenza virus infection

Influenza virus infects the airway epithelium. The connective tissue underneath the epithelium consists of extracellular matrix (ECM) produced mainly by fibroblasts. Small airway fibrosis, characterized by fibroblast activation an... ver más

31/08/2025

HMGU

190K€

Presupuesto del proyecto: 190K€

Líder del proyecto

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-05-04

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

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Cerrada hace 2 años

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1 Participantes

HMGU

189.69K€ | Lider

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Duración del proyecto: 27 meses Fecha Inicio: 2023-05-04
Fecha Fin: 2025-08-31

Líder del proyecto

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 190K€

Descripción del proyecto Influenza virus infects the airway epithelium. The connective tissue underneath the epithelium consists of extracellular matrix (ECM) produced mainly by fibroblasts. Small airway fibrosis, characterized by fibroblast activation and excessive deposition of ECM, is emerging as the key driver of the progression of chronic obstructive pulmonary disease (COPD), a very common and life-threatening lung disease for which no cure exists. Irreversible progression of COPD is often triggered by influenza virus infection. However, causative mechanisms between influenza virus infection and small airway fibrosis have not been explored. In this project, the fellow will infect an advanced co-culture model of patient-derived airway epithelial cells and fibroblasts from the human lung to mimic the microenvironment of the airway. Cellular and molecular profiling of the fibroblasts will be performed by an unbiased approach using integrated and interdisciplinary methods. Especially, a unique mass spectrometry and bioinformatics workflow for deep molecular profiling of the ECM will be combined with state-of-the art single cell RNA-sequence analysis to discover profibrotic readouts. Then, she will use cells from COPD patients to translate the findings to the clinic. Finally, she will establish a host-gene specific knockdown co-culture model to elucidate the role of a specific protein that interacts with the ECM and assess the druggability of this potential target. The fellow is a pathologist from Japan with extensive experience in infection with animal models. Her expertise and knowledge in disease pathology will be integrated with the host's prestigious scientific environment. Establishment of international connections will facilitate her to become an academic leader with a unique and multidisciplinary profile to combat infectious diseases of the lung.

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