Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

EPINER2007

Financiado

Cerrado

Epigenetics and DNA repair. Is a chromatin remodeling process involved in the hi...

Epigenetics and DNA repair. Is a chromatin remodeling process involved in the higher UV sensitivity of nucleotide excision repair defective cells? The knowledge on regulatory roles of epigenetic mechanisms (heritable changes in the genome function without a change in the DNA sequence) has grown very fast during the last decade since they can be the target for treating severa... ver más

13/05/2010

UNITUS

234K€

Presupuesto del proyecto: 234K€

Líder del proyecto

UNIVERSITA DEGLI STUDI DELLA TUSCIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2010-05-13 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNITUS

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

EPINER2007 Epigenetics and DNA repair. Is a chromatin remodeling proces... 15K€ Cerrado

CHROMATINREPAIRCODE CHROMATIN REPAIR CODE Hacking the chromatin code for DNA re... 2M€ Cerrado

ERC-ID Excision Repair and chromatin interaction dynamics 3M€ Cerrado

OXIDNA-REPAIR-CHROMA Unraveling the role of Nucleotide Excision Repair factors an... 168K€ Cerrado

TRANSREACT TFIIH as a crucial actor in genome expression and repair 2M€ Cerrado

REMIND Epigenome maintenance in response to DNA damage 2M€ Cerrado

Líder del proyecto

UNIVERSITA DEGLI STUDI DELLA TUSCIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 234K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The knowledge on regulatory roles of epigenetic mechanisms (heritable changes in the genome function without a change in the DNA sequence) has grown very fast during the last decade since they can be the target for treating several pathologies related to cancer and neurodegeneration. In the base of these diseases have also been found deficiencies in DNA repair mechanisms. In this respect, two human syndromes (Xeroderma Pigmentosum and Cockayne’s Syndrome) affecting one of the major DNA repair systems in human cells called nucleotide excision repair, characterized by sensitivity to UV irradiation, become an interesting model to contribute to unravel the link between chromatin remodeling processes and DNA repair. Expected results on the possible influence of chromatin remodeling processes to the higher sensitivity to UV radiation of Cockayne’s Syndrome cells will lead to perform further investigations to understand how these mechanisms are involved in the development of cancer and/or neurodegeneration found in these patients. Since the proposed investigation require a multidisciplinary study (cytogenetics, molecular biology and immunocytochemestry), it will become of the utmost importance not only for the research activity planned to carry out at the Laboratory of Prof. Palitti, since this line of research fits very well with the purposes already established by the Network of Excellence (NoE – Epigenetic Network created by several laboratories from Europe) supported by the FP6 program from the European Community; but also for having the possibility to incorporate new methodologies and strategies to continue with the study of possible links between epigenetic and DNA repair in our laboratory in Uruguay with the aim to initiate studies on epigenetic therapy mainly applied to facilitate chemotherapy treatment of cancer diseases.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores