Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

GutSense

Financiado

Cerrado

Environmental control of physiology through the brain-gut axis

A series of tightly controlled processes ensure that energy is either stored or consumed within an organism. This control is central to survival and prosperity of the animal, yet we only partly understand it. Communication between... ver más

31/12/2028

MINISTERE DE L'ENS...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

MINISTERE DE L'ENSEIGNEMENT SUPERIEUR ET DE... No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-12-13

ERC-2023-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

MINISTERE DE L'ENSEIGNEMENT...

1.93M€ | Lider

Proyectos interesantes

FoodConnect

Medical Technol...

Applied Physics

150K€ Cerrado

BRAINGUTTALK

Medical Technol...

Data Science

1M€ Cerrado

FeedHypNet

Medical Technol...

Applied Physics

2M€ Cerrado

PID2020-120029GB-I00

Medical Technol...

Applied Physics

448K€ Cerrado

WATCH

Medical Technol...

Applied Physics

10M€ Cerrado

BFU2013-47265-R

Medical Technol...

Applied Physics

197K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 60 meses Fecha Inicio: 2023-12-13
Fecha Fin: 2028-12-31

Líder del proyecto

MINISTERE DE L'ENSEIGNEMENT SUPERIEUR ET DE... No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto A series of tightly controlled processes ensure that energy is either stored or consumed within an organism. This control is central to survival and prosperity of the animal, yet we only partly understand it. Communication between the brain and the gut, the so called brain-gut axis, has emerged as a key player in regulating aspects of animal physiology by directly affecting energy stores. Nevertheless, due to the astonishing anatomical complexity of the underlying neural circuits in mammals, an in depth understanding of the cellular and molecular mechanisms controlling this axis is still lacking. Using the simpler yet functionally comparable Drosophila brain-gut axis as a model system, I have recently shown that adult enteric neurons are functionally plastic. This constitutes a physiological feature highly relevant for the adjustment of food intake by the animal to meet energy demands. I explored this in females in the context reproduction, where mechanisms underlying appetite regulation are evolutionary conserved across multiple species. Building on my expertise, I will now investigate the long-standing question on how environmental factors, such as dietary habits or levels of physical activity, impact the function of the brain-gut axis. For GutSense, I will leverage the unique experimental opportunities available in Drosophila to address the role of gut-neurons in metabolic adaptation: (a) characterize neurons which respond to these environmental cues, and the relevant neural circuits and mediators (b) identify the target tissues and the nature of inter-organ signals involved (c) investigate the impact of timing and duration of exposure to these factors, on metabolic adaptation. Through these, I will uncover basic and likely evolutionary conserved mechanisms and better understand the context-dependent tolerance of metabolic challenges. Such insight can lead the way in elucidating the contribution of brain-gut networks to the development of pathophysiology.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores